ENSMUSG00000026249


Mus musculus

Features
Gene ID: ENSMUSG00000026249
  
Biological name :Serpine2
  
Synonyms : Q07235 / serine (or cysteine) peptidase inhibitor, clade E, member 2 / Serpine2
  
Possible biological names infered from orthology : P07093 / serpin family E member 2
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C4
Gene start: 79794197
Gene end: 79861180
  
Corresponding Affymetrix probe sets: 10355984 (MoGene1.0st)   1416666_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140065
Ensembl peptide - ENSMUSP00000140255
Ensembl peptide - ENSMUSP00000027467
NCBI entrez gene - 20720     See in Manteia.
MGI - MGI:101780
RefSeq - NM_009255
RefSeq - XM_006496459
RefSeq Peptide - NP_033281
swissprot - A0A087WQM1
swissprot - Q07235
swissprot - Q543R5
swissprot - A0A087WQ70
Ensembl - ENSMUSG00000026249
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpine2ENSDARG00000029353Danio rerio
 SERPINE2ENSGALG00000005135Gallus gallus
 P07093ENSG00000135919Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Serpine1 / serine (or cysteine) peptidase inhibitor, clade E, member 1 / P05121* / serpin family E member 1*ENSMUSG0000003741138
O35684 / Serpini1 / serine (or cysteine) peptidase inhibitor, clade I, member 1 / Q99574* / serpin family I member 1*ENSMUSG0000002783434
Q9JK88 / Serpini2 / serine (or cysteine) peptidase inhibitor, clade I, member 2 / O75830* / serpin family I member 2*ENSMUSG0000003413932
P32261 / Serpinc1 / serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 / P01008* / serpin family C member 1*ENSMUSG0000002671529
Q9D7P9 / Serpinb12 / Serpin B12 / Q96P63* / serpin family B member 12*ENSMUSG0000005995629
Q9D695 / Serpinb7 / Serpin B7 / O75635* / serpin family B member 7*ENSMUSG0000006700128
Q9CQV3 / Serpinb11 / Serpin B11 / Q96P15* / serpin family B member 11 (gene/pseudogene)*ENSMUSG0000002632728
Serpine3 / serpin family E member 3 / A8MV23*ENSMUSG0000009115527
P19324 / Serpinh1 / Serpin H1 / P50454* / serpin family H member 1*ENSMUSG0000007043623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0010466 negative regulation of peptidase activity IMP
 biological_processGO:0010544 negative regulation of platelet activation IMP
 biological_processGO:0010757 negative regulation of plasminogen activation IMP
 biological_processGO:0010766 negative regulation of sodium ion transport IMP
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0010955 negative regulation of protein processing IC
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IGI
 biological_processGO:0021683 cerebellar granular layer morphogenesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030195 negative regulation of blood coagulation IEA
 biological_processGO:0030308 negative regulation of cell growth IGI
 biological_processGO:0032940 secretion by cell ISO
 biological_processGO:0033363 secretory granule organization ISO
 biological_processGO:0042177 negative regulation of protein catabolic process ISO
 biological_processGO:0042628 mating plug formation IMP
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IGI
 biological_processGO:0048505 regulation of timing of cell differentiation IMP
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0050974 detection of mechanical stimulus involved in sensory perception IMP
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0060384 innervation IMP
 biological_processGO:0061108 seminal vesicle epithelium development IMP
 biological_processGO:0090331 negative regulation of platelet aggregation IMP
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031091 platelet alpha granule IEA
 cellular_componentGO:0031232 extrinsic component of external side of plasma membrane IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity ISO
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005539 glycosaminoglycan binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001377 abnormal copulation "reduced or absent attempt of sexual contact between a male and a receptive female " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0001909 reduced NMDA receptor mediated synaptic activity in barrel cortex "lower than normal levels of excitatory synaptic current in the barrel cortex" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:64064]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0003607 abnormal prostate physiology "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0004220 abnormal peripheral nervous system regeneration "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010211 abnormal acute phase protein level "deviation from the normal levels of the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0013320 dilated seminal vesicles "an expansion in the lumen volume of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system, as by stretching or distention" [MGI:Anna]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0013899 abnormal seminal vesicle epithelium morphology "any structural anomaly of the pseudostratified columnar epithelium that lines the seminal vesicles and consists of tall, non-ciliated columnar cells and short, rounded basal cells that rest on the basal lamina; polarized columnar cells show features typical of secretory epithelium, including a well-developed Golgi complex, abundant rough endoplasmic reticulum, numerous mitochondria, and apical secretory vesicles; basal cells are the stem cells from which the columnar cells are derived" [ISBN:0781767903, ISBN:1455703079, MGI:Anna]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

 MP:0013903 abnormal seminal vesicle fluid composition "any alteration in the expected chemical makeup or appearance of the whitish yellow alkaline fluid secreted by the seminal vesicles that constitutes 60-70 percent of the ejaculate in humans; the secretory product of the columnar epithelial cell, which may be seen in the lumen of seminal vesicles, is strongly acidophilic; it contains large amounts of fructose (used by spermatozoa as an energy source for motility) in addition to water, K+ ions, phosphorylcholine, prostaglandins, flavins, citrate, ascorbic acid, and several amino acids and enzymes; seminal vesicle fluid is responsible for coagulation of the ejaculate, can alter sperm motility and capacitation, and acts as an immunosuppressant in the female reproductive tract" [http://www.lab.anhb.uwa.edu.au/mb140/corepages/malerepro/malerepro.htm#LabSeminal, https://en.wikipedia.org/wiki/Seminal_vesicle#Function, ISBN:0781767903, ISBN:1455703079, MGI:Anna]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026249 Q07235 / Serpine2 / serine (or cysteine) peptidase inhibitor, clade E, member 2 / P07093* / serpin family E member 2*  / complex
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / complex / reaction






 

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