ENSG00000135919


Homo sapiens

Features
Gene ID: ENSG00000135919
  
Biological name :SERPINE2
  
Synonyms : P07093 / SERPINE2 / serpin family E member 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q36.1
Gene start: 223975112
Gene end: 224039319
  
Corresponding Affymetrix probe sets: 212190_at (Human Genome U133 Plus 2.0 Array)   227487_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000258405
Ensembl peptide - ENSP00000386412
Ensembl peptide - ENSP00000415786
Ensembl peptide - ENSP00000408452
Ensembl peptide - ENSP00000399655
Ensembl peptide - ENSP00000394518
Ensembl peptide - ENSP00000386969
NCBI entrez gene - 5270     See in Manteia.
OMIM - 177010
RefSeq - XM_005246641
RefSeq - XM_017004332
RefSeq - XM_017004331
RefSeq - XM_017004330
RefSeq - XM_017004329
RefSeq - NM_001136528
RefSeq - NM_001136530
RefSeq - NM_006216
RefSeq Peptide - NP_001130000
RefSeq Peptide - NP_001130002
RefSeq Peptide - NP_006207
swissprot - P07093
swissprot - C9K031
swissprot - A0A024R451
swissprot - A0A024R498
swissprot - C9JN98
swissprot - C9JRK5
Ensembl - ENSG00000135919
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpine2ENSDARG00000029353Danio rerio
 SERPINE2ENSGALG00000005135Gallus gallus
 Q07235ENSMUSG00000026249Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P05121 / SERPINE1 / serpin family E member 1ENSG0000010636639
Q99574 / SERPINI1 / serpin family I member 1ENSG0000016353632
O75830 / SERPINI2 / serpin family I member 2ENSG0000011420430
A8MV23 / SERPINE3 / serpin family E member 3ENSG0000025330930
Q96P63 / SERPINB12 / serpin family B member 12ENSG0000016663428
P01008 / SERPINC1 / serpin family C member 1ENSG0000011760128
O75635 / SERPINB7 / serpin family B member 7ENSG0000016639625
P50454 / SERPINH1 / serpin family H member 1ENSG0000014925722
Q96P15 / SERPINB11 / serpin family B member 11 (gene/pseudogene)ENSG0000020607221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010544 negative regulation of platelet activation IEA
 biological_processGO:0010757 negative regulation of plasminogen activation IEA
 biological_processGO:0010766 negative regulation of sodium ion transport IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0010955 negative regulation of protein processing IC
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0021683 cerebellar granular layer morphogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030195 negative regulation of blood coagulation IDA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030334 regulation of cell migration NAS
 biological_processGO:0032940 secretion by cell IEA
 biological_processGO:0033363 secretory granule organization IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042628 mating plug formation IEA
 biological_processGO:0045861 negative regulation of proteolysis IDA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IEA
 biological_processGO:0048505 regulation of timing of cell differentiation IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IDA
 biological_processGO:0050974 detection of mechanical stimulus involved in sensory perception IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060384 innervation IEA
 biological_processGO:0061108 seminal vesicle epithelium development IEA
 biological_processGO:0090331 negative regulation of platelet aggregation ISS
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0031091 platelet alpha granule IDA
 cellular_componentGO:0031232 extrinsic component of external side of plasma membrane IDA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:1903561 extracellular vesicle HDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IMP
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005539 glycosaminoglycan binding IDA
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135919 P07093 / SERPINE2 / serpin family E member 2  / complex
 ENSG00000180210 F2 / P00734 / coagulation factor II, thrombin  / complex / reaction






 

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