ENSMUSG00000027834


Mus musculus

Features
Gene ID: ENSMUSG00000027834
  
Biological name :Serpini1
  
Synonyms : O35684 / serine (or cysteine) peptidase inhibitor, clade I, member 1 / Serpini1
  
Possible biological names infered from orthology : Q99574 / serpin family I member 1
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E3
Gene start: 75557547
Gene end: 75643495
  
Corresponding Affymetrix probe sets: 10492628 (MoGene1.0st)   1416702_at (Mouse Genome 430 2.0 Array)   1443756_at (Mouse Genome 430 2.0 Array)   1448443_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123845
Ensembl peptide - ENSMUSP00000029423
NCBI entrez gene - 20713     See in Manteia.
MGI - MGI:1194506
RefSeq - NM_009250
RefSeq - XM_006501225
RefSeq Peptide - NP_033276
swissprot - E0CYW0
swissprot - O35684
Ensembl - ENSMUSG00000027834
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpini1ENSDARG00000034168Danio rerio
 Q90935ENSGALG00000009470Gallus gallus
 Q99574ENSG00000163536Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JK88 / Serpini2 / serine (or cysteine) peptidase inhibitor, clade I, member 2 / O75830* / serpin family I member 2*ENSMUSG0000003413935
Q07235 / Serpine2 / serine (or cysteine) peptidase inhibitor, clade E, member 2 / P07093* / serpin family E member 2*ENSMUSG0000002624933
P32261 / Serpinc1 / serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 / P01008* / serpin family C member 1*ENSMUSG0000002671532
Serpine1 / serine (or cysteine) peptidase inhibitor, clade E, member 1 / P05121* / serpin family E member 1*ENSMUSG0000003741130
Q9D7P9 / Serpinb12 / Serpin B12 / Q96P63* / serpin family B member 12*ENSMUSG0000005995628
Q9D695 / Serpinb7 / Serpin B7 / O75635* / serpin family B member 7*ENSMUSG0000006700127
Q9CQV3 / Serpinb11 / Serpin B11 / Q96P15* / serpin family B member 11 (gene/pseudogene)*ENSMUSG0000002632727
P19324 / Serpinh1 / Serpin H1 / P50454* / serpin family H member 1*ENSMUSG0000007043627
Serpine3 / serpin family E member 3 / A8MV23*ENSMUSG0000009115525


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034774 secretory granule lumen IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0060205 cytoplasmic vesicle lumen IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: B6.129-Gt(ROSA)26Sortm1(cre/Esr1)Nat

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: B6.129-Gt(ROSA)26Sortm1(cre/Esr1)Nat

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: B6.129-Gt(ROSA)26Sortm1(cre/Esr1)Nat

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: B6.129-Gt(ROSA)26Sortm1(cre/Esr1)Nat

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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