ENSMUSG00000037411


Mus musculus

Features
Gene ID: ENSMUSG00000037411
  
Biological name :Serpine1
  
Synonyms : serine (or cysteine) peptidase inhibitor, clade E, member 1 / Serpine1
  
Possible biological names infered from orthology : P05121 / serpin family E member 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 137061504
Gene end: 137072268
  
Corresponding Affymetrix probe sets: 10534667 (MoGene1.0st)   1419149_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039586
Ensembl peptide - ENSMUSP00000076728
NCBI entrez gene - 18787     See in Manteia.
MGI - MGI:97608
RefSeq - NM_008871
RefSeq Peptide - NP_032897
swissprot - G5E899
Ensembl - ENSMUSG00000037411
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpine1ENSDARG00000056795Danio rerio
 P05121ENSG00000106366Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q07235 / Serpine2 / serine (or cysteine) peptidase inhibitor, clade E, member 2 / P07093* / serpin family E member 2*ENSMUSG0000002624938
O35684 / Serpini1 / serine (or cysteine) peptidase inhibitor, clade I, member 1 / Q99574* / serpin family I member 1*ENSMUSG0000002783430
Q9JK88 / Serpini2 / serine (or cysteine) peptidase inhibitor, clade I, member 2 / O75830* / serpin family I member 2*ENSMUSG0000003413929
Q9CQV3 / Serpinb11 / Serpin B11 / Q96P15* / serpin family B member 11 (gene/pseudogene)*ENSMUSG0000002632728
P32261 / Serpinc1 / serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 / P01008* / serpin family C member 1*ENSMUSG0000002671527
Q9D695 / Serpinb7 / Serpin B7 / O75635* / serpin family B member 7*ENSMUSG0000006700126
Q9D7P9 / Serpinb12 / Serpin B12 / Q96P63* / serpin family B member 12*ENSMUSG0000005995625
Serpine3 / serpin family E member 3 / A8MV23*ENSMUSG0000009115524
P19324 / Serpinh1 / Serpin H1 / P50454* / serpin family H member 1*ENSMUSG0000007043622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001300 chronological cell aging IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010757 negative regulation of plasminogen activation IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0033629 negative regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0035491 positive regulation of leukotriene production involved in inflammatory response IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0051918 negative regulation of fibrinolysis IEA
 biological_processGO:0061044 negative regulation of vascular wound healing IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IEA
 biological_processGO:0090399 replicative senescence IEA
 biological_processGO:0097187 dentinogenesis IEA
 biological_processGO:1901331 positive regulation of odontoblast differentiation IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2000098 negative regulation of smooth muscle cell-matrix adhesion IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
ECM proteoglycans
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Tg(Ins2-TFRC/OVA)296Wehi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(MSR1-Plau)1Ddi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Tg(Ins2-TFRC/OVA)296Wehi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(MSR1-Plau)1Ddi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002498 abnormal acute inflammation "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S-Serpine1tm1Mlg Ldlrtm1Her

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Tg(Ins2-TFRC/OVA)296Wehi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lepob/Lepob,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Tg(Ins2-TFRC/OVA)296Wehi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129-Serpine1tm1Mlg Apoetm1Unc

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S-Serpine1tm1Mlg Ldlrtm1Her

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Tg(Ins2-TFRC/OVA)296Wehi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1

Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Lepob/Lepob,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1

Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0011506 glomerular crescent "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]
Show

Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021822 Plau / P06869 / plasminogen activator, urokinase / P00749*  / complex / reaction
 ENSMUSG00000031538 Plat / P11214 / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B / P00750* / plasminogen activator, tissue type*  / reaction / complex
 ENSMUSG00000017344 Vtn / P29788 / vitronectin / P04004*  / reaction / complex
 ENSMUSG00000046223 Plaur / P35456 / plasminogen activator, urokinase receptor / Q03405*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr