ENSMUSG00000046223


Mus musculus

Features
Gene ID: ENSMUSG00000046223
  
Biological name :Plaur
  
Synonyms : P35456 / plasminogen activator, urokinase receptor / Plaur
  
Possible biological names infered from orthology : Q03405
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 24462484
Gene end: 24475968
  
Corresponding Affymetrix probe sets: 10550906 (MoGene1.0st)   1452521_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145540
Ensembl peptide - ENSMUSP00000145632
Ensembl peptide - ENSMUSP00000002284
NCBI entrez gene - 18793     See in Manteia.
MGI - MGI:97612
RefSeq - NM_011113
RefSeq - XM_006539639
RefSeq - XM_006539640
RefSeq Peptide - NP_035243
swissprot - P35456
swissprot - A0A0U1RNF3
swissprot - A0A0U1RNN0
swissprot - Q545X5
Ensembl - ENSMUSG00000046223
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLAURENSG00000011422Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016054  Ly-6 antigen/uPA receptor-like
 IPR018363  CD59 antigen, conserved site
 IPR033084  Urokinase plasminogen activator surface receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030162 regulation of proteolysis IEA
 biological_processGO:0038195 urokinase plasminogen activator signaling pathway IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA
 biological_processGO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030377 urokinase plasminogen activator receptor activity IEA


Pathways (from Reactome)
Pathway description
Attachment of GPI anchor to uPAR
Neutrophil degranulation
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ay/a,Npbwr1tm1Rck/Npbwr1tm1Rck
Genetic Background: involves: 129P/Ola * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002467 impaired neutrophil phagocytosis "reduced ability of these leukocytes to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ay/a,Npbwr1tm1Rck/Npbwr1tm1Rck
Genetic Background: involves: 129P/Ola * C57BL/6J

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003246 loss of GABA neurons "loss of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: A/J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013498 trachea inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the trachea" [MGI:Anna]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000062345 P12388 / Serpinb2 / serine (or cysteine) peptidase inhibitor, clade B, member 2 / P05120* / serpin family B member 2*  / complex / reaction
 ENSMUSG00000021822 Plau / P06869 / plasminogen activator, urokinase / P00749*  / complex / reaction
 ENSMUSG00000059481 Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*  / reaction
 ENSMUSG00000037411 Serpine1 / serine (or cysteine) peptidase inhibitor, clade E, member 1 / P05121* / serpin family E member 1*  / reaction / complex
 ENSMUSG00000039047 Pigk / Q9CXY9 / phosphatidylinositol glycan anchor biosynthesis, class K / Q92643*  / reaction
 ENSMUSG00000073678 Pgap1 / Q3UUQ7 / GPI inositol-deacylase / Q75T13* / post-GPI attachment to proteins 1*  / reaction






 

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