ENSMUSG00000062345


Mus musculus

Features
Gene ID: ENSMUSG00000062345
  
Biological name :Serpinb2
  
Synonyms : P12388 / serine (or cysteine) peptidase inhibitor, clade B, member 2 / Serpinb2
  
Possible biological names infered from orthology : P05120 / serpin family B member 2
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E2.1
Gene start: 107511423
Gene end: 107535478
  
Corresponding Affymetrix probe sets: 10349157 (MoGene1.0st)   1419082_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009356
Ensembl peptide - ENSMUSP00000065277
Ensembl peptide - ENSMUSP00000114751
Ensembl peptide - ENSMUSP00000119795
NCBI entrez gene - 18788     See in Manteia.
MGI - MGI:97609
RefSeq - NM_011111
RefSeq - XM_011247942
RefSeq - NM_001174170
RefSeq Peptide - NP_001167641
RefSeq Peptide - NP_035241
swissprot - F6QN99
swissprot - P12388
swissprot - Q542A3
swissprot - F6ZFV0
Ensembl - ENSMUSG00000062345
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SERPINB2ENSGALG00000019552Gallus gallus
 P05120ENSG00000197632Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VHP7 / Serpinb1b / serine (or cysteine) peptidase inhibitor, clade B, member 1b / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000005102941
Q9D154 / Serpinb1a / serine (or cysteine) peptidase inhibitor, clade B, member 1a / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000004473441
Q60854 / Serpinb6a / serine (or cysteine) peptidase inhibitor, clade B, member 6a / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000006014741
Serpinb6b / serine (or cysteine) peptidase inhibitor, clade B, member 6b / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000004284239
Q5SV42 / Serpinb1c / serine (or cysteine) peptidase inhibitor, clade B, member 1c / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000007904939
Serpinb9 / serine (or cysteine) peptidase inhibitor, clade B, member 9 / P50453* / serpin family B member 9*ENSMUSG0000004582739
O08800 / Serpinb8 / Serpin B8 / P50452* / serpin family B member 8*ENSMUSG0000002631539
Serpinb9b / serine (or cysteine) peptidase inhibitor, clade B, member 9b / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000002140338
Serpinb9e / serine (or cysteine) peptidase inhibitor, clade B, member 9e / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000006234238
Serpinb9d / serine (or cysteine) peptidase inhibitor, clade B, member 9d / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000005426638
Serpinb3a / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000004459438
Gm11397 / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000007145237
Serpinb6c / serine (or cysteine) peptidase inhibitor, clade B, member 6c / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000005218037
Serpinb9g / serine (or cysteine) peptidase inhibitor, clade B, member 9g / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000005772637
Serpinb9f / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000003832737
Serpinb6d / serine (or cysteine) peptidase inhibitor, clade B, member 6d / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000004788937
Serpinb3b / serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B / P29508* / P48594* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000007360237
Serpinb3d / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000005801736
Serpinb9c / serine (or cysteine) peptidase inhibitor, clade B, member 9c / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000002140436
Serpinb3c / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000007360136


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR015556  Plasminogen activator inhibitor-2
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irs1smla/Irs1smla,Serpinb2tm2Dgi/Serpinb2tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046223 Plaur / P35456 / plasminogen activator, urokinase receptor / Q03405*  / complex / reaction
 ENSMUSG00000021822 Plau / P06869 / plasminogen activator, urokinase / P00749*  / complex / reaction






 

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