ENSMUSG00000044734


Mus musculus

Features
Gene ID: ENSMUSG00000044734
  
Biological name :Serpinb1a
  
Synonyms : Q9D154 / serine (or cysteine) peptidase inhibitor, clade B, member 1a / Serpinb1a
  
Possible biological names infered from orthology : P30740 / SERPINB1 / serpin family B member 1
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.2
Gene start: 32842092
Gene end: 32851185
  
Corresponding Affymetrix probe sets: 10408557 (MoGene1.0st)   1416318_at (Mouse Genome 430 2.0 Array)   1448301_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075690
Ensembl peptide - ENSMUSP00000089257
NCBI entrez gene - 66222     See in Manteia.
MGI - MGI:1913472
RefSeq - NM_025429
RefSeq - XM_006516724
RefSeq Peptide - NP_079705
swissprot - Q9D154
swissprot - Z4YK03
Ensembl - ENSMUSG00000044734
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpinb1ENSDARG00000055416Danio rerio
 serpinb1l2ENSDARG00000070396Danio rerio
 SERPINB1ENSGALG00000019555Gallus gallus
 P30740ENSG00000021355Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VHP7 / Serpinb1b / serine (or cysteine) peptidase inhibitor, clade B, member 1b / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000005102987
Q5SV42 / Serpinb1c / serine (or cysteine) peptidase inhibitor, clade B, member 1c / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000007904983
Q60854 / Serpinb6a / serine (or cysteine) peptidase inhibitor, clade B, member 6a / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000006014749
Serpinb6b / serine (or cysteine) peptidase inhibitor, clade B, member 6b / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000004284248
Serpinb6c / serine (or cysteine) peptidase inhibitor, clade B, member 6c / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000005218047
O08800 / Serpinb8 / Serpin B8 / P50452* / serpin family B member 8*ENSMUSG0000002631547
Serpinb3a / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000004459446
Serpinb9d / serine (or cysteine) peptidase inhibitor, clade B, member 9d / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000005426646
Serpinb3b / serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B / P29508* / P48594* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000007360246
Serpinb9b / serine (or cysteine) peptidase inhibitor, clade B, member 9b / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000002140346
Serpinb9 / serine (or cysteine) peptidase inhibitor, clade B, member 9 / P50453* / serpin family B member 9*ENSMUSG0000004582746
Serpinb9e / serine (or cysteine) peptidase inhibitor, clade B, member 9e / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000006234246
Gm11397 / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000007145245
Serpinb9f / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000003832745
P12388 / Serpinb2 / serine (or cysteine) peptidase inhibitor, clade B, member 2 / P05120* / serpin family B member 2*ENSMUSG0000006234545
Serpinb9g / serine (or cysteine) peptidase inhibitor, clade B, member 9g / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000005772645
Serpinb3c / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000007360144
Serpinb3d / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000005801744
Serpinb6d / serine (or cysteine) peptidase inhibitor, clade B, member 6d / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000004788943
Serpinb9c / serine (or cysteine) peptidase inhibitor, clade B, member 9c / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000002140443


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR015557  Leukocyte elastase inhibitor (serpin B1)
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0042176 regulation of protein catabolic process IPI
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004782 abnormal surfactant physiology "anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dicer1tm1.1Doca/Dicer1tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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