ENSMUSG00000045827


Mus musculus

Features
Gene ID: ENSMUSG00000045827
  
Biological name :Serpinb9
  
Synonyms : serine (or cysteine) peptidase inhibitor, clade B, member 9 / Serpinb9
  
Possible biological names infered from orthology : P50453 / serpin family B member 9
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.2
Gene start: 33003250
Gene end: 33017957
  
Corresponding Affymetrix probe sets: 10404429 (MoGene1.0st)   1422601_at (Mouse Genome 430 2.0 Array)   1439790_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006391
Ensembl peptide - ENSMUSP00000099002
NCBI entrez gene - 20723     See in Manteia.
MGI - MGI:106603
RefSeq - XM_017315468
RefSeq - NM_009256
RefSeq - XM_006516628
RefSeq - XM_006516629
RefSeq - XM_006516625
RefSeq - XM_006516626
RefSeq Peptide - NP_033282
swissprot - O08797
Ensembl - ENSMUSG00000045827
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpinb14ENSDARG00000091801Danio rerio
 serpinb1l1ENSDARG00000095830Danio rerio
 serpinb1l3ENSDARG00000014556Danio rerio
 serpinb1l4ENSDARG00000096888Danio rerio
 zgc:173729ENSDARG00000057263Danio rerio
 SERPINB6LENSGALG00000012866Gallus gallus
 P50453ENSG00000170542Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Serpinb9b / serine (or cysteine) peptidase inhibitor, clade B, member 9b / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000002140377
Serpinb9e / serine (or cysteine) peptidase inhibitor, clade B, member 9e / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000006234272
Gm11397 / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000007145272
Serpinb9f / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000003832772
Serpinb9g / serine (or cysteine) peptidase inhibitor, clade B, member 9g / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000005772672
Serpinb9d / serine (or cysteine) peptidase inhibitor, clade B, member 9d / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000005426671
Serpinb9c / serine (or cysteine) peptidase inhibitor, clade B, member 9c / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000002140468
Q60854 / Serpinb6a / serine (or cysteine) peptidase inhibitor, clade B, member 6a / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000006014755
O08800 / Serpinb8 / Serpin B8 / P50452* / serpin family B member 8*ENSMUSG0000002631554
Serpinb6c / serine (or cysteine) peptidase inhibitor, clade B, member 6c / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000005218053
Serpinb6b / serine (or cysteine) peptidase inhibitor, clade B, member 6b / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000004284253
Q9D154 / Serpinb1a / serine (or cysteine) peptidase inhibitor, clade B, member 1a / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000004473447
Serpinb6e / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000006924847
Q8VHP7 / Serpinb1b / serine (or cysteine) peptidase inhibitor, clade B, member 1b / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000005102946
Serpinb6d / serine (or cysteine) peptidase inhibitor, clade B, member 6d / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000004788946
Q5SV42 / Serpinb1c / serine (or cysteine) peptidase inhibitor, clade B, member 1c / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000007904945
Serpinb3a / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000004459444
Serpinb3d / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000005801743
P12388 / Serpinb2 / serine (or cysteine) peptidase inhibitor, clade B, member 2 / P05120* / serpin family B member 2*ENSMUSG0000006234543
Serpinb3c / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000007360143


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR000240  Serpin B9/maspin
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001913 T cell mediated cytotoxicity IMP
 biological_processGO:0002438 acute inflammatory response to antigenic stimulus IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006955 immune response ISO
 biological_processGO:0009617 response to bacterium ISO
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010951 negative regulation of endopeptidase activity ISO
 biological_processGO:0033668 negative regulation by symbiont of host apoptotic process ISO
 biological_processGO:0042270 protection from natural killer cell mediated cytotoxicity ISO
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0070233 negative regulation of T cell apoptotic process IMP
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dzip1lwarpy/Dzip1lwarpy
Genetic Background: involves: C57BL/6 * CD-1

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dzip1lwarpy/Dzip1lwarpy
Genetic Background: involves: C57BL/6 * CD-1

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm,Prrx2tm1Mjk/Prrx2tm1Mjk
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002436 abnormal cytotoxic T cell morphology/development "anomalous structure, formation, or numbers of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm,Prrx2tm1Mjk/Prrx2tm1Mjk
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Gzmbtm1Ley/Gzmbtm1Ley,Serpinb9tm1Arp/Serpinb9tm1Arp
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dzip1lwarpy/Dzip1lwarpy
Genetic Background: involves: C57BL/6 * CD-1

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm,Prrx2tm1Mjk/Prrx2tm1Mjk
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Gzmbtm1Ley/Gzmbtm1Ley,Serpinb9tm1Arp/Serpinb9tm1Arp
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm,Prrx2tm1Mjk/Prrx2tm1Mjk
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm,Prrx2tm1Mjk/Prrx2tm1Mjk
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm,Prrx2tm1Mjk/Prrx2tm1Mjk
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
Show

Allelic Composition: Gzmbtm1Ley/Gzmbtm1Ley,Serpinb9tm1Arp/Serpinb9tm1Arp
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm,Prrx2tm1Mjk/Prrx2tm1Mjk
Genetic Background: involves: 129S4/SvJaeSor

 MP:0012191 decreased cytotoxic T cell apoptosis "decrease in the number of cytotoxic T cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Dzip1lwarpy/Dzip1lwarpy
Genetic Background: involves: C57BL/6 * CD-1

Allelic Composition: Gzmbtm1Ley/Gzmbtm1Ley,Serpinb9tm1.1Pib/Serpinb9tm1.1Pib
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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