ENSMUSG00000044594


Mus musculus

Features
Gene ID: ENSMUSG00000044594
  
Biological name :Serpinb3a
  
Synonyms : Serpinb3a
  
Possible biological names infered from orthology : P29508 / P48594 / SERPINB3 / SERPINB4 / serpin family B member 3 / serpin family B member 4
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.1
Gene start: 107045587
Gene end: 107052303
  
Corresponding Affymetrix probe sets: 10357072 (MoGene1.0st)   1437517_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027567
Ensembl peptide - ENSMUSP00000108337
NCBI entrez gene - 20248     See in Manteia.
MGI - MGI:3573933
RefSeq - NM_009126
RefSeq Peptide - NP_033152
swissprot - G3X9V8
Ensembl - ENSMUSG00000044594
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P29508ENSG00000057149Homo sapiens
 P48594ENSG00000206073Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Serpinb3b / serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B / P29508* / P48594* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000007360287
Serpinb3c / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000007360183
Serpinb3d / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000005801782
Q8CDC0 / Serpinb13 / Serpin B13 / Q9UIV8* / serpin family B member 13*ENSMUSG0000004877549
Q8VHP7 / Serpinb1b / serine (or cysteine) peptidase inhibitor, clade B, member 1b / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000005102945
Q9D154 / Serpinb1a / serine (or cysteine) peptidase inhibitor, clade B, member 1a / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000004473445
Q60854 / Serpinb6a / serine (or cysteine) peptidase inhibitor, clade B, member 6a / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000006014744
O08800 / Serpinb8 / Serpin B8 / P50452* / serpin family B member 8*ENSMUSG0000002631543
Serpinb9d / serine (or cysteine) peptidase inhibitor, clade B, member 9d / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000005426643
Serpinb6b / serine (or cysteine) peptidase inhibitor, clade B, member 6b / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000004284243
Serpinb6c / serine (or cysteine) peptidase inhibitor, clade B, member 6c / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000005218043
Q5SV42 / Serpinb1c / serine (or cysteine) peptidase inhibitor, clade B, member 1c / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000007904942
Serpinb9 / serine (or cysteine) peptidase inhibitor, clade B, member 9 / P50453* / serpin family B member 9*ENSMUSG0000004582742
Gm11397 / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000007145242
Serpinb9g / serine (or cysteine) peptidase inhibitor, clade B, member 9g / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000005772642
Serpinb9b / serine (or cysteine) peptidase inhibitor, clade B, member 9b / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000002140342
Serpinb9f / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000003832742
Serpinb9e / serine (or cysteine) peptidase inhibitor, clade B, member 9e / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000006234242
Serpinb9c / serine (or cysteine) peptidase inhibitor, clade B, member 9c / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000002140441
P12388 / Serpinb2 / serine (or cysteine) peptidase inhibitor, clade B, member 2 / P05120* / serpin family B member 2*ENSMUSG0000006234541


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity ISO
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0042270 protection from natural killer cell mediated cytotoxicity ISO
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular ISO
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0019899 enzyme binding ISO


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0010862 decreased respiratory mucosa goblet cell number "reduced number of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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