ENSG00000057149


Homo sapiens

Features
Gene ID: ENSG00000057149
  
Biological name :SERPINB3
  
Synonyms : P29508 / SERPINB3 / serpin family B member 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q21.33
Gene start: 63655197
Gene end: 63661963
  
Corresponding Affymetrix probe sets: 209719_x_at (Human Genome U133 Plus 2.0 Array)   209720_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000329498
Ensembl peptide - ENSP00000283752
NCBI entrez gene - 6317     See in Manteia.
OMIM - 600517
RefSeq - NM_006919
RefSeq Peptide - NP_008850
swissprot - P29508
Ensembl - ENSG00000057149
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Serpinb3aENSMUSG00000044594Mus musculus
 Serpinb3bENSMUSG00000073602Mus musculus
 Serpinb3cENSMUSG00000073601Mus musculus
 Serpinb3dENSMUSG00000058017Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P48594 / SERPINB4 / serpin family B member 4ENSG0000020607392
Q9UIV8 / SERPINB13 / serpin family B member 13ENSG0000019764158
P30740 / SERPINB1 / serpin family B member 1ENSG0000002135548
P35237 / SERPINB6 / serpin family B member 6ENSG0000012457046
P48595 / SERPINB10 / serpin family B member 10ENSG0000024255045
P50453 / SERPINB9 / serpin family B member 9ENSG0000017054244
P50452 / SERPINB8 / serpin family B member 8ENSG0000016640143
P05120 / SERPINB2 / serpin family B member 2ENSG0000019763243
P36952 / SERPINB5 / serpin family B member 5ENSG0000020607533


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0010950 positive regulation of endopeptidase activity IDA
 biological_processGO:0010951 negative regulation of endopeptidase activity IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0035425 autocrine signaling IMP
 biological_processGO:0038001 paracrine signaling IMP
 biological_processGO:0043086 negative regulation of catalytic activity IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043508 negative regulation of JUN kinase activity IMP
 biological_processGO:0045861 negative regulation of proteolysis IDA
 biological_processGO:0046718 viral entry into host cell IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001618 virus receptor activity IDA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IMP
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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