ENSG00000021355


Homo sapiens

Features
Gene ID: ENSG00000021355
  
Biological name :SERPINB1
  
Synonyms : P30740 / SERPINB1 / serpin family B member 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p25.2
Gene start: 2832332
Gene end: 2842006
  
Corresponding Affymetrix probe sets: 212268_at (Human Genome U133 Plus 2.0 Array)   213572_s_at (Human Genome U133 Plus 2.0 Array)   228726_at (Human Genome U133 Plus 2.0 Array)   239213_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370115
NCBI entrez gene - 1992     See in Manteia.
OMIM - 130135
RefSeq - XM_011514335
RefSeq - NM_030666
RefSeq - XM_011514333
RefSeq - XM_011514334
RefSeq Peptide - NP_109591
swissprot - P30740
swissprot - V9HWH1
Ensembl - ENSG00000021355
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpinb1ENSDARG00000055416Danio rerio
 serpinb1l2ENSDARG00000070396Danio rerio
 SERPINB1ENSGALG00000019555Gallus gallus
 Q5SV42ENSMUSG00000079049Mus musculus
 Q8VHP7ENSMUSG00000051029Mus musculus
 Q9D154ENSMUSG00000044734Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P50452 / SERPINB8 / serpin family B member 8ENSG0000016640152
P35237 / SERPINB6 / serpin family B member 6ENSG0000012457051
P50453 / SERPINB9 / serpin family B member 9ENSG0000017054251
P05120 / SERPINB2 / serpin family B member 2ENSG0000019763250
P29508 / SERPINB3 / serpin family B member 3ENSG0000005714950
P48594 / SERPINB4 / serpin family B member 4ENSG0000020607350
Q9UIV8 / SERPINB13 / serpin family B member 13ENSG0000019764147
P48595 / SERPINB10 / serpin family B member 10ENSG0000024255047
P36952 / SERPINB5 / serpin family B member 5ENSG0000020607539


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR015557  Leukocyte elastase inhibitor (serpin B1)
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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