ENSG00000011422


Homo sapiens

Features
Gene ID: ENSG00000011422
  
Biological name :PLAUR
  
Synonyms : plasminogen activator, urokinase receptor / PLAUR / Q03405
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.31
Gene start: 43646095
Gene end: 43670547
  
Corresponding Affymetrix probe sets: 210845_s_at (Human Genome U133 Plus 2.0 Array)   211924_s_at (Human Genome U133 Plus 2.0 Array)   214866_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473055
Ensembl peptide - ENSP00000471881
Ensembl peptide - ENSP00000472511
Ensembl peptide - ENSP00000221264
Ensembl peptide - ENSP00000339328
Ensembl peptide - ENSP00000342049
Ensembl peptide - ENSP00000468863
Ensembl peptide - ENSP00000470029
Ensembl peptide - ENSP00000470050
Ensembl peptide - ENSP00000471241
Ensembl peptide - ENSP00000471307
Ensembl peptide - ENSP00000471525
NCBI entrez gene - 5329     See in Manteia.
OMIM - 173391
RefSeq - XM_017026873
RefSeq - NM_001005376
RefSeq - NM_001005377
RefSeq - NM_001301037
RefSeq - NM_002659
RefSeq - XM_005258990
RefSeq - XM_011527027
RefSeq - XM_011527028
RefSeq - XM_011527029
RefSeq - XM_011527030
RefSeq - XM_011527031
RefSeq - XM_017026872
RefSeq Peptide - NP_001005377
RefSeq Peptide - NP_001287966
RefSeq Peptide - NP_002650
RefSeq Peptide - NP_001005376
swissprot - M0R0L1
swissprot - M0R0Y4
swissprot - M0R1I2
swissprot - M0R2E9
swissprot - M0R383
swissprot - M0QX27
swissprot - Q03405
swissprot - M0QYR6
swissprot - M0QYS6
swissprot - M0R0H5
Ensembl - ENSG00000011422
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PlaurENSMUSG00000046223Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016054  Ly-6 antigen/uPA receptor-like
 IPR018363  CD59 antigen, conserved site
 IPR033084  Urokinase plasminogen activator surface receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0016255 attachment of GPI anchor to protein TAS
 biological_processGO:0030162 regulation of proteolysis IEA
 biological_processGO:0038195 urokinase plasminogen activator signaling pathway IEA
 biological_processGO:0042730 fibrinolysis TAS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043388 positive regulation of DNA binding IDA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IMP
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IMP
 biological_processGO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0019898 extrinsic component of membrane TAS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071438 invadopodium membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0030377 urokinase plasminogen activator receptor activity IEA


Pathways (from Reactome)
Pathway description
Attachment of GPI anchor to uPAR
Neutrophil degranulation
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106366 P05121 / SERPINE1 / serpin family E member 1  / complex / reaction
 ENSG00000122861 PLAU / P00749 / plasminogen activator, urokinase  / complex / reaction
 ENSG00000122194 PLG / P00747 / plasminogen  / reaction
 ENSG00000197632 P05120 / SERPINB2 / serpin family B member 2  / complex / reaction
 ENSG00000142892 PIGK / Q92643 / phosphatidylinositol glycan anchor biosynthesis class K  / reaction
 ENSG00000197121 PGAP1 / Q75T13 / post-GPI attachment to proteins 1  / reaction






 

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