ENSMUSG00000058952


Mus musculus

Features
Gene ID: ENSMUSG00000058952
  
Biological name :Cfi
  
Synonyms : Cfi / Mus musculus complement component factor i (Cfi), transcript variant 2, mRNA. / Q61129
  
Possible biological names infered from orthology : AC126283.2 / complement factor I / P05156
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 129835884
Gene end: 129875332
  
Corresponding Affymetrix probe sets: 10496001 (MoGene1.0st)   1418724_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077074
Ensembl peptide - ENSMUSP00000142975
NCBI entrez gene - 12630     See in Manteia.
MGI - MGI:105937
RefSeq - XM_006500963
RefSeq - NM_001329552
RefSeq - NM_007686
RefSeq - XM_006500961
RefSeq - XM_006500962
RefSeq Peptide - NP_001316481
RefSeq Peptide - NP_031712
swissprot - Q61129
swissprot - A0A0G2JF07
Ensembl - ENSMUSG00000058952
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01073265.1ENSDARG00000099425Danio rerio
 CFIENSGALG00000012126Gallus gallus
 AC126283.2ENSG00000285330Homo sapiens
 CFIENSG00000205403Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VHK8 / Tmprss11d / Transmembrane protease serine 11D Transmembrane protease serine 11D non-catalytic chain Transmembrane protease serine 11D catalytic chain / O60235* / transmembrane seri...ENSMUSG0000006125920
Q5S248 / Tmprss11e / Transmembrane protease serine 11E Transmembrane protease serine 11E non-catalytic chain Transmembrane protease serine 11E catalytic chain / Q9UL52* / transmembrane seri...ENSMUSG0000005453719
Q14C59 / Tmprss11b / Transmembrane protease serine 11B-like protein / Q86T26* / transmembrane serine protease 11B*ENSMUSG0000003586119
Q1JRP2 / Tmprss11c / transmembrane protease, serine 11cENSMUSG0000006118418
Q8BHM9 / Tmprss11f / Transmembrane protease serine 11F / Q6ZWK6* / transmembrane serine protease 11F*ENSMUSG0000004876418
Q8BZ10 / Tmprss11g / transmembrane protease, serine 11gENSMUSG0000007945118
Q3UQ41 / Tmprss11a / Transmembrane protease serine 11A / Q6ZMR5* / transmembrane serine protease 11A*ENSMUSG0000007284517
F2YMG0 / Prss56 / Serine protease 56 / P0CW18*ENSMUSG0000003648015
Acr / P23578 / Acrosin Acrosin light chain Acrosin heavy chain / P10323* / acrosin*ENSMUSG0000002262215
Q3V0Q7 / Tmprss12 / Transmembrane protease serine 12 / Q86WS5* / transmembrane serine protease 12*ENSMUSG0000004563114


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR002350  Kazal domain
 IPR003884  Factor I / membrane attack complex
 IPR009003  Peptidase S1, PA clan
 IPR017448  SRCR-like domain
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR036055  LDL receptor-like superfamily
 IPR036058  Kazal domain superfamily
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cfhtm1Mbo/Cfhtm1Mbo,Cfitm1Mcp/Cfitm1Mcp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
Show

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cfhtm1Mbo/Cfh+,Cfitm1Mcp/Cfitm1Mcp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cfhtm1Mbo/Cfhtm1Mbo,Cfitm1Mcp/Cfitm1Mcp
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / reaction / complex
 ENSMUSG00000073418 C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...  / reaction / complex
 ENSMUSG00000058952 Cfi / Q61129 / Mus musculus complement component factor i (Cfi), transcript variant 2, mRNA. / P05156* / AC126283.2* / complement factor I*  / complex / reaction
 ENSMUSG00000016493 Cd46 / O88174 / Membrane cofactor protein / P15529* / CD46 molecule*  / complex / reaction






 

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