ENSGALG00000012126


Gallus gallus

Features
Gene ID: ENSGALG00000012126
  
Biological name :CFI
  
Synonyms : CFI
  
Possible biological names infered from orthology : AC126283.2 / complement factor I / Mus musculus complement component factor i (Cfi), transcript variant 2, mRNA. / P05156 / Q61129
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 58493683
Gene end: 58506491
  
Corresponding Affymetrix probe sets: Gga.7813.1.S1_at (Chicken Array)   Gga.7813.2.S1_at (Chicken Array)   GgaAffx.23798.3.S1_s_at (Chicken Array)   GgaAffx.23798.4.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019783
NCBI entrez gene - 428773     See in Manteia.
RefSeq - NM_001272018
RefSeq Peptide - NP_001258947
swissprot - F1NF64
Ensembl - ENSGALG00000012126
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01073265.1ENSDARG00000099425Danio rerio
 AC126283.2ENSG00000285330Homo sapiens
 CFIENSG00000205403Homo sapiens
 CfiENSMUSG00000058952Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UQ41* / Q5S248* / Q6ZMR5* / Q8BZ10* / Q8VHK8* / O60235* / Q9UL52* / TMPRSS11D* / TMPRSS11A* / TMPRSS11E* / Tmprss11g* / transmembrane serine protease 11E* / transmembrane serine protease ...ENSGALG0000001179219
PRSS56 / serine protease 56 / F2YMG0* / P0CW18*ENSGALG0000004541316
ACR / acrosin / P10323* / P23578* / Acrosin Acrosin light chain Acrosin heavy chain*ENSGALG0000003436615
TMPRSS12 / transmembrane serine protease 12 / Q3V0Q7* / Q86WS5* / Transmembrane protease serine 12 *ENSGALG0000003655013
Q1JRP2* / Tmprss11c* / transmembrane protease, serine 11c*ENSGALG0000002613410
ENSGALG000000458916


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR002350  Kazal domain
 IPR003884  Factor I / membrane attack complex
 IPR009003  Peptidase S1, PA clan
 IPR017448  SRCR-like domain
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0030449 regulation of complement activation TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of complement cascades
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002431 CFH* / CFHR3* / CFHR1* / CFHR5* / CFHR4* / CFHR2* / P06909* / Q9BXR6* / Gm4788* / Q92496* / Q03591* / Q02985* / P36980* / P08603* / BX248415.1* / complement factor H* / complement factor H ...  / reaction / complex
 ENSGALG00000012126 CFI / P05156* / Q61129* / AC126283.2* / complement factor I* / Mus musculus complement component factor i (Cfi), transcript variant 2, mRNA.*  / complex / reaction






 

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