ENSMUSG00000036480


Mus musculus

Features
Gene ID: ENSMUSG00000036480
  
Biological name :Prss56
  
Synonyms : F2YMG0 / Prss56 / Serine protease 56
  
Possible biological names infered from orthology : P0CW18
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C5
Gene start: 87183313
Gene end: 87188405
  
Corresponding Affymetrix probe sets: 10348144 (MoGene1.0st)   1429647_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138773
NCBI entrez gene - 69453     See in Manteia.
MGI - MGI:1916703
RefSeq - XM_006529860
RefSeq - NM_027084
RefSeq - XM_006529858
RefSeq - XM_006529859
RefSeq Peptide - NP_081360
swissprot - F2YMG0
Ensembl - ENSMUSG00000036480
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prss56ENSDARG00000053158Danio rerio
 PRSS56ENSGALG00000045413Gallus gallus
 P0CW18ENSG00000237412Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acr / P23578 / Acrosin Acrosin light chain Acrosin heavy chain / P10323* / acrosin*ENSMUSG0000002262219
Q8BHM9 / Tmprss11f / Transmembrane protease serine 11F / Q6ZWK6* / transmembrane serine protease 11F*ENSMUSG0000004876418
Q3UQ41 / Tmprss11a / Transmembrane protease serine 11A / Q6ZMR5* / transmembrane serine protease 11A*ENSMUSG0000007284518
Q8VHK8 / Tmprss11d / Transmembrane protease serine 11D Transmembrane protease serine 11D non-catalytic chain Transmembrane protease serine 11D catalytic chain / O60235* / transmembrane seri...ENSMUSG0000006125918
Q1JRP2 / Tmprss11c / transmembrane protease, serine 11cENSMUSG0000006118417
Q14C59 / Tmprss11b / Transmembrane protease serine 11B-like protein / Q86T26* / transmembrane serine protease 11B*ENSMUSG0000003586117
Q5S248 / Tmprss11e / Transmembrane protease serine 11E Transmembrane protease serine 11E non-catalytic chain Transmembrane protease serine 11E catalytic chain / Q9UL52* / transmembrane seri...ENSMUSG0000005453717
Q3V0Q7 / Tmprss12 / Transmembrane protease serine 12 / Q86WS5* / transmembrane serine protease 12*ENSMUSG0000004563116
Q8BZ10 / Tmprss11g / transmembrane protease, serine 11gENSMUSG0000007945116
Cfi / Q61129 / Mus musculus complement component factor i (Cfi), transcript variant 2, mRNA. / P05156* / AC126283.2* / complement factor I*ENSMUSG0000005895215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0043010 camera-type eye development IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0001059 optic nerve atrophy "wasting of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac

 MP:0002697 abnormal eye size "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac

 MP:0002698 abnormal sclera morphology "structural anomaly of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0004221 abnormal iridocorneal angle "any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C57BL/6J-Prss56glcr4

 MP:0004223 hypoplastic trabecular meshwork "reduced size of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MESH:A09.371.060.932, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C57BL/6J-Prss56glcr4

 MP:0005098 abnormal choroid morphology "anomalous structure of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac

 MP:0005258 ocular hypertension "abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C57BL/6J-Prss56glcr4

 MP:0005387 immune system phenotype 
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0009829 enlarged eye anterior chamber "increased size of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MESH:A09.371.060.067, MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C57BL/6J-Prss56glcr4

 MP:0010081 posterior microphthalmia "reduced average size of the back of the eye" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C57BL/6J-Prss56glcr4

Allelic Composition: Prss56glcr4/Prss56glcr4
Genetic Background: C3A.Cg-Prss56glcr4 Pde6b+

 MP:0013436 increased CD8-positive, naive alpha-beta T cell number "increase in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0013771 decreased effector memory T-helper cell number "reduction in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype" [MGI:Saran]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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