ENSMUSG00000022622


Mus musculus

Features
Gene ID: ENSMUSG00000022622
  
Biological name :Acr
  
Synonyms : Acr / Acrosin Acrosin light chain Acrosin heavy chain / P23578
  
Possible biological names infered from orthology : acrosin / P10323
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E3
Gene start: 89568326
Gene end: 89574585
  
Corresponding Affymetrix probe sets: 10426284 (MoGene1.0st)   1449895_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023295
Ensembl peptide - ENSMUSP00000154827
Ensembl peptide - ENSMUSP00000155369
Ensembl peptide - ENSMUSP00000155444
NCBI entrez gene - 11434     See in Manteia.
MGI - MGI:87884
RefSeq - XM_006520300
RefSeq - NM_001205049
RefSeq - NM_001277245
RefSeq - NM_001277246
RefSeq - NM_001277247
RefSeq - NM_013455
RefSeq - XM_006520299
RefSeq Peptide - NP_001264175
RefSeq Peptide - NP_001264176
RefSeq Peptide - NP_038483
RefSeq Peptide - NP_001191978
RefSeq Peptide - NP_001264174
swissprot - P23578
Ensembl - ENSMUSG00000022622
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACRENSGALG00000034366Gallus gallus
 ACRENSG00000100312Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F2YMG0 / Prss56 / Serine protease 56 / P0CW18*ENSMUSG0000003648027
Q3UQ41 / Tmprss11a / Transmembrane protease serine 11A / Q6ZMR5* / transmembrane serine protease 11A*ENSMUSG0000007284526
Q8BHM9 / Tmprss11f / Transmembrane protease serine 11F / Q6ZWK6* / transmembrane serine protease 11F*ENSMUSG0000004876425
Q14C59 / Tmprss11b / Transmembrane protease serine 11B-like protein / Q86T26* / transmembrane serine protease 11B*ENSMUSG0000003586124
Q1JRP2 / Tmprss11c / transmembrane protease, serine 11cENSMUSG0000006118424
Q8VHK8 / Tmprss11d / Transmembrane protease serine 11D Transmembrane protease serine 11D non-catalytic chain Transmembrane protease serine 11D catalytic chain / O60235* / transmembrane seri...ENSMUSG0000006125923
Q5S248 / Tmprss11e / Transmembrane protease serine 11E Transmembrane protease serine 11E non-catalytic chain Transmembrane protease serine 11E catalytic chain / Q9UL52* / transmembrane seri...ENSMUSG0000005453723
Q8BZ10 / Tmprss11g / transmembrane protease, serine 11gENSMUSG0000007945123
Q3V0Q7 / Tmprss12 / Transmembrane protease serine 12 / Q86WS5* / transmembrane serine protease 12*ENSMUSG0000004563122
Cfi / Q61129 / Mus musculus complement component factor i (Cfi), transcript variant 2, mRNA. / P05156* / AC126283.2* / complement factor I*ENSMUSG0000005895220


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR012267  Peptidase S1A, acrosin
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007190 activation of adenylate cyclase activity IEA
 biological_processGO:0007338 single fertilization IMP
 biological_processGO:0007339 binding of sperm to zona pellucida IGI
 biological_processGO:0007340 acrosome reaction TAS
 biological_processGO:0007341 penetration of zona pellucida IMP
 biological_processGO:0048545 response to steroid hormone IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005798 Golgi-associated vesicle IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043159 acrosomal matrix TAS
 molecular_functionGO:0004040 amidase activity ISS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005537 mannose binding IEA
 molecular_functionGO:0008144 drug binding ISS
 molecular_functionGO:0008233 peptidase activity IMP
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042806 fucose binding ISS


Pathways (from Reactome)
Pathway description
Acrosome Reaction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hist1h1ttm1Ais/Hist1h1ttm1Ais
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1atm1Drab/Hist1h1atm1Drab,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J * CD-1

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

 MP:0005411 delayed fertilization "a lag in the normal time of onset of the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acp5tm1Ahdm/Acp5+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Acrtm1Tba/Acrtm1Tba
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * ICR)

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022622 Acr / P23578 / Acrosin Acrosin light chain Acrosin heavy chain / P10323* / acrosin*  / complex / reaction






 

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