ENSG00000100312


Homo sapiens

Features
Gene ID: ENSG00000100312
  
Biological name :ACR
  
Synonyms : ACR / acrosin / P10323
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.33
Gene start: 50738196
Gene end: 50745334
  
Corresponding Affymetrix probe sets: 207427_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000216139
Ensembl peptide - ENSP00000435120
NCBI entrez gene - 49     See in Manteia.
OMIM - 102480
RefSeq - NM_001097
RefSeq Peptide - NP_001088
swissprot - E9PLV5
swissprot - P10323
Ensembl - ENSG00000100312
  
Related genetic diseases (OMIM): 102480 - ?Male infertility due to acrosin deficiency
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACRENSGALG00000034366Gallus gallus
 AcrENSMUSG00000022622Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P0CW18 / PRSS56 / serine protease 56ENSG0000023741228
Q86T26 / TMPRSS11B / transmembrane serine protease 11BENSG0000018587327
Q6ZMR5 / TMPRSS11A / transmembrane serine protease 11AENSG0000018705426
Q6ZWK6 / TMPRSS11F / transmembrane serine protease 11FENSG0000019809226
O60235 / TMPRSS11D / transmembrane serine protease 11DENSG0000015380226
Q86WS5 / TMPRSS12 / transmembrane serine protease 12ENSG0000018645225
Q9UL52 / TMPRSS11E / transmembrane serine protease 11EENSG0000008712824
CFI / P05156 / complement factor IENSG0000020540323
AC126283.2ENSG0000028533019


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR012267  Peptidase S1A, acrosin
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002077 acrosome matrix dispersal NAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007190 activation of adenylate cyclase activity IDA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007339 binding of sperm to zona pellucida IEA
 biological_processGO:0007340 acrosome reaction TAS
 biological_processGO:0007341 penetration of zona pellucida IEA
 biological_processGO:0048545 response to steroid hormone IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005798 Golgi-associated vesicle IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043159 acrosomal matrix TAS
 molecular_functionGO:0002020 protease binding TAS
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0004040 amidase activity ISS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005507 copper ion binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005537 mannose binding IDA
 molecular_functionGO:0008144 drug binding ISS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding NAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042806 fucose binding ISS


Pathways (from Reactome)
Pathway description
Acrosome Reaction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100312 ACR / P10323 / acrosin  / complex / reaction






 

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