ENSMUSG00000046186


Mus musculus

Features
Gene ID: ENSMUSG00000046186
  
Biological name :Cd109
  
Synonyms : Cd109 / CD109 antigen / Q8R422
  
Possible biological names infered from orthology : CD109 molecule / Q6YHK3
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E1
Gene start: 78615546
Gene end: 78716253
  
Corresponding Affymetrix probe sets: 10587383 (MoGene1.0st)   1425658_at (Mouse Genome 430 2.0 Array)   1436346_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091330
NCBI entrez gene - 235505     See in Manteia.
MGI - MGI:2445221
RefSeq - NM_153098
RefSeq Peptide - NP_694738
swissprot - A6MDD3
swissprot - Q8R422
Ensembl - ENSMUSG00000046186
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd109ENSDARG00000060609Danio rerio
 CD109ENSGALG00000015910Gallus gallus
 CD109ENSG00000156535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pzp / Q61838 / Pregnancy zone protein Alpha-2-macroglobulin 165 kDa subunit Alpha-2-macroglobulin 35 kDa subunitENSMUSG0000003035926
A2m / Q6GQT1 / alpha-2-macroglobulin / P01023*ENSMUSG0000003011126
Mug2 / P28666 / Murinoglobulin-2 ENSMUSG0000003013126
Mug1 / P28665 / Murinoglobulin-1 ENSMUSG0000005990826
Gm7298ENSMUSG0000010802226
A2ml1 / Q3UU35 / alpha-2-macroglobulin like 1ENSMUSG0000004722824
C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...ENSMUSG0000002416423
C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...ENSMUSG0000007341823
Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*ENSMUSG0000002687420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR019565  Alpha-2-macroglobulin, thiol-ester bond-forming
 IPR019742  Alpha-2-macroglobulin, conserved site
 IPR036595  Alpha-macroglobulin, receptor-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IMP
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0045616 regulation of keratinocyte differentiation IMP
 biological_processGO:0061045 negative regulation of wound healing IEA
 biological_processGO:0072675 osteoclast fusion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0050431 transforming growth factor beta binding ISO


Pathways (from Reactome)
Pathway description
Platelet degranulation
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cd109tm1Mat/Cd109tm1Mat
Genetic Background: B6.129S6-Cd109tm1Mat

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cd109tm1Mat/Cd109tm1Mat
Genetic Background: B6.129S6-Cd109tm1Mat

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0009612 thick epidermis suprabasal layer 
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0009715 thick epidermis stratum basale "increased thickness of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0009794 sebaceous gland hyperplasia "overdevelopment and increased size of the sebum secreting glands of the hair shaft, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0010678 abnormal skin adnexa morphology "any structural anomaly of the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0010682 abnormal hair follicle infundibulum morphology "any structural anomaly of the most proximal part of the hair follicle relative to the epidermis, extending from the sebaceous duct to the epidermal surface" [PMID:19211055]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0010699 dilated hair follicles "the luminal space of the hair follicle is increased in volume or area, sometimes with an increase of contained fluid or sebum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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