ENSG00000156535


Homo sapiens

Features
Gene ID: ENSG00000156535
  
Biological name :CD109
  
Synonyms : CD109 / CD109 molecule / Q6YHK3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q13
Gene start: 73695785
Gene end: 73828316
  
Corresponding Affymetrix probe sets: 226545_at (Human Genome U133 Plus 2.0 Array)   229900_at (Human Genome U133 Plus 2.0 Array)   239719_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000287097
Ensembl peptide - ENSP00000388062
Ensembl peptide - ENSP00000404475
NCBI entrez gene - 135228     See in Manteia.
OMIM - 608859
RefSeq - XM_017010283
RefSeq - NM_001159587
RefSeq - NM_001159588
RefSeq - NM_133493
RefSeq - XM_005248659
RefSeq - XM_011535473
RefSeq Peptide - NP_001153059
RefSeq Peptide - NP_001153060
RefSeq Peptide - NP_598000
swissprot - Q6YHK3
Ensembl - ENSG00000156535
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd109ENSDARG00000060609Danio rerio
 CD109ENSGALG00000015910Gallus gallus
 Cd109ENSMUSG00000046186Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CPAMD8 / Q8IZJ3 / C3 and PZP like, alpha-2-macroglobulin domain containing 8ENSG0000016011131
PZP / P20742 / PZP, alpha-2-macroglobulin likeENSG0000012683827
A2ML1 / A8K2U0 / alpha-2-macroglobulin like 1ENSG0000016653527
A2M / P01023 / alpha-2-macroglobulinENSG0000017589927
C3 / P01024 / complement C3ENSG0000012573023
C4A / P0C0L4 / complement C4A (Rodgers blood group)ENSG0000024473123
C4B / P0C0L5 / complement C4B (Chido blood group)ENSG0000022438923
C5 / P01031 / complement C5ENSG0000010680420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR019565  Alpha-2-macroglobulin, thiol-ester bond-forming
 IPR019742  Alpha-2-macroglobulin, conserved site
 IPR036595  Alpha-macroglobulin, receptor-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006501 C-terminal protein lipidation TAS
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0045616 regulation of keratinocyte differentiation IEA
 biological_processGO:0061045 negative regulation of wound healing IDA
 biological_processGO:0072675 osteoclast fusion IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031092 platelet alpha granule membrane TAS
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0050431 transforming growth factor beta binding IPI


Pathways (from Reactome)
Pathway description
Platelet degranulation
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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