ENSG00000126838


Homo sapiens

Features
Gene ID: ENSG00000126838
  
Biological name :PZP
  
Synonyms : P20742 / PZP / PZP, alpha-2-macroglobulin like
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.31
Gene start: 9148840
Gene end: 9208370
  
Corresponding Affymetrix probe sets: 207330_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261336
Ensembl peptide - ENSP00000440811
NCBI entrez gene - 5858     See in Manteia.
OMIM - 176420
RefSeq - XM_017019766
RefSeq - NM_002864
RefSeq - XM_017019763
RefSeq - XM_017019764
RefSeq - XM_017019765
RefSeq - XM_011520804
RefSeq - XM_011520805
RefSeq - XM_011520806
RefSeq Peptide - NP_002855
swissprot - P20742
swissprot - F5GXY0
Ensembl - ENSG00000126838
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000031659Gallus gallus
 ENSGALG00000039764Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2M / P01023 / alpha-2-macroglobulinENSG0000017589972
A2ML1 / A8K2U0 / alpha-2-macroglobulin like 1ENSG0000016653537
CPAMD8 / Q8IZJ3 / C3 and PZP like, alpha-2-macroglobulin domain containing 8ENSG0000016011127
CD109 / Q6YHK3 / CD109 moleculeENSG0000015653526
C3 / P01024 / complement C3ENSG0000012573023
C4B / P0C0L5 / complement C4B (Chido blood group)ENSG0000022438922
C4A / P0C0L4 / complement C4A (Rodgers blood group)ENSG0000024473122
C5 / P01031 / complement C5ENSG0000010680420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR010916  TonB box, conserved site
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR019565  Alpha-2-macroglobulin, thiol-ester bond-forming
 IPR019742  Alpha-2-macroglobulin, conserved site
 IPR036595  Alpha-macroglobulin, receptor-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007565 female pregnancy TAS
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0004866 endopeptidase inhibitor activity TAS
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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