ENSMUSG00000025196


Mus musculus

Features
Gene ID: ENSMUSG00000025196
  
Biological name :Cpn1
  
Synonyms : carboxypeptidase N, polypeptide 1 / Cpn1 / Q9JJN5
  
Possible biological names infered from orthology : carboxypeptidase N subunit 1 / P15169
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 43956307
Gene end: 43986556
  
Corresponding Affymetrix probe sets: 10467887 (MoGene1.0st)   1417745_at (Mouse Genome 430 2.0 Array)   1440576_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026210
NCBI entrez gene - 93721     See in Manteia.
MGI - MGI:2135874
RefSeq - NM_030703
RefSeq - XM_011247407
RefSeq Peptide - NP_109628
swissprot - Q9JJN5
Ensembl - ENSMUSG00000025196
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpn1ENSDARG00000005185Danio rerio
 cpn1ENSDARG00000096728Danio rerio
 CPN1ENSGALG00000007090Gallus gallus
 CPN1ENSG00000120054Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cpd / O89001 / Carboxypeptidase D / O75976*ENSMUSG0000002084145
Cpe / Q00493 / Carboxypeptidase E / P16870*ENSMUSG0000003785245
Cpxm1 / Q9Z100 / Probable carboxypeptidase X1 / Q96SM3* / carboxypeptidase X, M14 family member 1*ENSMUSG0000002740844
Cpz / Q8R4V4 / carboxypeptidase Z / Q66K79*ENSMUSG0000003659643
Cpxm2 / carboxypeptidase X, M14 family member 2 / Q8N436*ENSMUSG0000003086242
Aebp1 / Q640N1 / Adipocyte enhancer-binding protein 1 / Q8IUX7* / AE binding protein 1*ENSMUSG0000002047340
Cpm / Q80V42 / carboxypeptidase M / P14384*ENSMUSG0000002018337


Protein motifs (from Interpro)
Interpro ID Name
 IPR000834  Peptidase M14, carboxypeptidase A
 IPR008969  Carboxypeptidase-like, regulatory domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0010815 bradykinin catabolic process IEA
 biological_processGO:0030070 insulin processing IBA
 biological_processGO:0051384 response to glucocorticoid IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0030141 secretory granule IBA
 cellular_componentGO:0043025 neuronal cell body IBA
 cellular_componentGO:0097060 synaptic membrane IBA
 molecular_functionGO:0004180 carboxypeptidase activity IDA
 molecular_functionGO:0004181 metallocarboxypeptidase activity IBA
 molecular_functionGO:0004185 serine-type carboxypeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002471 abnormal complement cascade "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw,Cpn1tm1Raw/Cpn1tm1Raw
Genetic Background: B6.129-C3ar1tm1Raw Cpn1tm1Raw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025196 Cpn1 / Q9JJN5 / carboxypeptidase N, polypeptide 1 / P15169* / carboxypeptidase N subunit 1*  / complex
 ENSMUSG00000023176 Cpn2 / Q9DBB9 / Carboxypeptidase N subunit 2 / P22792*  / complex
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / reaction






 

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