Manteia - Molecule gene

ENSMUSG00000037852

Mus musculus

Features

Gene ID:	ENSMUSG00000037852

Biological name :	Cpe

Synonyms :	Carboxypeptidase E / Cpe / Q00493

Possible biological names infered from orthology :	P16870

Species:	Mus musculus

Chr. number:	8
Strand:	-1
Band:	B3.1
Gene start:	64592542
Gene end:	64693054

Corresponding Affymetrix probe sets:	10578904 (MoGene1.0st) 1415949_at (Mouse Genome 430 2.0 Array) 1439437_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000048555 NCBI entrez gene - 12876 See in Manteia. MGI - MGI:101932 RefSeq - NM_013494 RefSeq Peptide - NP_038522 swissprot - Q00493 swissprot - Q543R4 Ensembl - ENSMUSG00000037852

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
cpe	ENSDARG00000055874	Danio rerio
CPE	ENSGALG00000027788	Gallus gallus
CPE	ENSG00000109472	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Cpd / O89001 / Carboxypeptidase D / O75976*	ENSMUSG00000020841	48
Cpz / Q8R4V4 / carboxypeptidase Z / Q66K79*	ENSMUSG00000036596	44
Cpn1 / Q9JJN5 / carboxypeptidase N, polypeptide 1 / P15169* / carboxypeptidase N subunit 1*	ENSMUSG00000025196	43
Cpxm1 / Q9Z100 / Probable carboxypeptidase X1 / Q96SM3* / carboxypeptidase X, M14 family member 1*	ENSMUSG00000027408	42
Cpxm2 / carboxypeptidase X, M14 family member 2 / Q8N436*	ENSMUSG00000030862	40
Aebp1 / Q640N1 / Adipocyte enhancer-binding protein 1 / Q8IUX7* / AE binding protein 1*	ENSMUSG00000020473	38
Cpm / Q80V42 / carboxypeptidase M / P14384*	ENSMUSG00000020183	35

Protein motifs (from Interpro)

Interpro ID	Name
IPR000834	Peptidase M14, carboxypeptidase A
IPR008969	Carboxypeptidase-like, regulatory domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0003214	cardiac left ventricle morphogenesis	IEA
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0016055	Wnt signaling pathway	IEA
biological_process	GO:0030070	insulin processing	IMP
biological_process	GO:0072657	protein localization to membrane	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IDA
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030141	secretory granule	IBA
cellular_component	GO:0030658	transport vesicle membrane	IEA
cellular_component	GO:0030667	secretory granule membrane	TAS
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
cellular_component	GO:0043025	neuronal cell body	IBA
cellular_component	GO:0097060	synaptic membrane	IBA
molecular_function	GO:0004180	carboxypeptidase activity	IMP
molecular_function	GO:0004181	metallocarboxypeptidase activity	IBA
molecular_function	GO:0004185	serine-type carboxypeptidase activity	IBA
molecular_function	GO:0008233	peptidase activity	TAS
molecular_function	GO:0008237	metallopeptidase activity	IEA
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0042043	neurexin family protein binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0050839	cell adhesion molecule binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000182	increased circulating LDL cholesterol level	"greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Sla^tm1Weis/Sla^tm1Weis,Zap70^tm1Weis/Zap70^tm1Weis Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
MP:0000505	reduced digestive secretion	"decrease in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Coq6^{tm1b(EUCOMM)Hmgu}/Coq6^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Coq6^{tm1b(EUCOMM)Hmgu}/J
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001257	increased body length	"increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Tgm2^tm1.1Rmgr/Tgm2⁺,Tg(HDexon1)62Gpb/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0001261	obese	"excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Sla^tm1Weis/Sla^tm1Weis,Zap70^tm1Weis/Zap70^tm1Weis Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Coq6^{tm1b(EUCOMM)Hmgu}/Coq6^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Coq6^{tm1b(EUCOMM)Hmgu}/J
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cpe^{tm1b(EUCOMM)Hmgu}/Cpe^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cpe^{tm1b(EUCOMM)Hmgu}/Ieg
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001433	polyphagia	"eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tgm2^tm1.1Rmgr/Tgm2⁺,Tg(HDexon1)62Gpb/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0001488	increased startle reflex	"reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cpe^{tm1b(EUCOMM)Hmgu}/Cpe^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cpe^{tm1b(EUCOMM)Hmgu}/Ieg
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tgm2^tm1.1Rmgr/Tgm2⁺,Tg(HDexon1)62Gpb/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0001526	abnormal placing response	"altered ability to stretch and lift the forelimbs and head to grab a close edge " [J:66943, MGI:cml]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0001556	increased circulating HDL cholesterol level	"higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Sla^tm1Weis/Sla^tm1Weis,Zap70^tm1Weis/Zap70^tm1Weis Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0001752	abnormal hypothalamus secretion	"altered ability of the hypothalamus to release its contents" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Sla^tm1Weis/Sla^tm1Weis,Zap70^tm1Weis/Zap70^tm1Weis Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Cpe^{tm1b(EUCOMM)Hmgu}/Cpe^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cpe^{tm1b(EUCOMM)Hmgu}/Ieg
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tgm2^tm1.1Rmgr/Tgm2⁺,Tg(HDexon1)62Gpb/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tgm2^tm1.1Rmgr/Tgm2⁺,Tg(HDexon1)62Gpb/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Sla^tm1Weis/Sla^tm1Weis,Zap70^tm1Weis/Zap70^tm1Weis Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002106	abnormal muscle physiology	"anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tgm2^tm1.1Rmgr/Tgm2⁺,Tg(HDexon1)62Gpb/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0002664	decreased circulating adrenocorticotropin level	"decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Cpe^fat/Cpe^fat,Fina1^C57BLKS/J/Fina1^C57BLKS/J Genetic Background: involves: C57BLKS/J * HRS/J
MP:0002757	reduced vertical activity	"lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cpe^{tm1b(EUCOMM)Hmgu}/Cpe^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cpe^{tm1b(EUCOMM)Hmgu}/Ieg
MP:0003953	abnormal hormone level	"aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0003973	increased pituitary hormone level	"greater than the expected amount of any of the pituitary hormones in the blood or tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0004262	abnormal physical strength	"altered ability of an organism to exert force on physical objects or of the body to support its load" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0004732	decreased circulating gastrin level	"reduced concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cpe^{tm1b(EUCOMM)Hmgu}/Cpe^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cpe^{tm1b(EUCOMM)Hmgu}/Ieg
MP:0005117	increased circulating pituitary hormone level	"greater than expected concentraton of any of the pituitary hormones in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0005123	increased circulating growth hormone level	"greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0005137	increased growth hormone level	"greater than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0005145	increased circulating VLDL cholesterol level	"greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J Allelic Composition: Cpe^fat/Cpe^fat,Find2^C57BLKS/J/Find2^C57BLKS/J Genetic Background: involves: C57BLKS/J * HRS/J
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0005217	abnormal pancreatic beta cell morphology	"malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sla^tm1Weis/Sla^tm1Weis,Zap70^tm1Weis/Zap70^tm1Weis Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cpe^{tm1b(EUCOMM)Hmgu}/Cpe^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cpe^{tm1b(EUCOMM)Hmgu}/Ieg
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0005450	abnormal energy expenditure	"utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0005455	increased weight gain	"greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]	Show Allelic Composition: Ift57^tm2Dwni/Ift57^tm2Dwni Genetic Background: involves: 129S1/SvImJ * C57BL/6J
MP:0005457	abnormal percent body fat	"more or less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0005480	increased circulating triiodothyronine level	"greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0005491	islet cell hyperplasia	"increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sla^tm1Weis/Sla^tm1Weis,Zap70^tm1Weis/Zap70^tm1Weis Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0005498	hyporesponsive to tactile stimuli	"reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cpe^fat/Cpe^fat,Find2^C57BLKS/J/Find2^C57BLKS/J Genetic Background: involves: C57BLKS/J * HRS/J Allelic Composition: Cpe^fat/Cpe^fat,Find1^HRS/J/Find1^HRS/J Genetic Background: involves: C57BLKS/J * HRS/J
MP:0005669	increased circulating leptin level	"greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0009142	decreased prepulse inhibition	"decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cpe^{tm1b(EUCOMM)Hmgu}/Cpe^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cpe^{tm1b(EUCOMM)Hmgu}/Ieg
MP:0009167	increased pancreatic islet number	"increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Sla^tm1Weis/Sla^tm1Weis,Zap70^tm1Weis/Zap70^tm1Weis Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
MP:0009255	degranulated pancreatic beta cells	"insulin-secreting cells of the pancreas do not contain vesicles containing insulin" [MGI:acv "Alicia Valenzuela, Genetic Resources Curator"]	Show Allelic Composition: Sla^tm1Weis/Sla^tm1Weis,Zap70^tm1Weis/Zap70^tm1Weis Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sla^tm1Weis/Sla^tm1Weis,Zap70^tm1Weis/Zap70^tm1Weis Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cpe^fat/Cpe^fat,Fina1^C57BLKS/J/Fina1^C57BLKS/J Genetic Background: involves: C57BLKS/J * HRS/J
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cpe^{tm1b(EUCOMM)Hmgu}/Cpe^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cpe^{tm1b(EUCOMM)Hmgu}/Ieg
MP:0010378	increased respiratory quotient	"increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0010379	decreased respiratory quotient	"reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cpe^{tm1b(EUCOMM)Hmgu}/Cpe^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cpe^{tm1b(EUCOMM)Hmgu}/Ieg
MP:0011049	impaired adaptive thermogenesis	"inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]	Show Allelic Composition: Cpe^fat/Cpe^fat Genetic Background: BKSChpLt.HRS-Cpe^fat/J
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Cpe^{tm1b(EUCOMM)Hmgu}/Cpe^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cpe^{tm1b(EUCOMM)Hmgu}/Ieg
MP:0013279	increased fasted circulating glucose level	"increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Cpe^{tm1b(EUCOMM)Hmgu}/Cpe^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cpe^{tm1b(EUCOMM)Hmgu}/Ieg

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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