ENSG00000109472


Homo sapiens

Features
Gene ID: ENSG00000109472
  
Biological name :CPE
  
Synonyms : carboxypeptidase E / CPE / P16870
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q32.3
Gene start: 165361194
Gene end: 165498320
  
Corresponding Affymetrix probe sets: 201116_s_at (Human Genome U133 Plus 2.0 Array)   201117_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000416601
Ensembl peptide - ENSP00000427629
Ensembl peptide - ENSP00000424830
Ensembl peptide - ENSP00000423699
Ensembl peptide - ENSP00000386104
NCBI entrez gene - 1363     See in Manteia.
OMIM - 114855
RefSeq - NM_001873
RefSeq Peptide - NP_001864
swissprot - C9JE88
swissprot - D6RF88
swissprot - P16870
swissprot - H0YAM0
swissprot - D6R930
Ensembl - ENSG00000109472
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpeENSDARG00000055874Danio rerio
 CPEENSGALG00000027788Gallus gallus
 CpeENSMUSG00000037852Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CPD / O75976 / carboxypeptidase DENSG0000010858248
CPN1 / P15169 / carboxypeptidase N subunit 1ENSG0000012005444
CPZ / Q66K79 / carboxypeptidase ZENSG0000010962543
CPXM1 / Q96SM3 / carboxypeptidase X, M14 family member 1ENSG0000008888242
CPXM2 / Q8N436 / carboxypeptidase X, M14 family member 2ENSG0000012189840
AEBP1 / Q8IUX7 / AE binding protein 1ENSG0000010662438
CPM / P14384 / carboxypeptidase MENSG0000013567834


Protein motifs (from Interpro)
Interpro ID Name
 IPR000834  Peptidase M14, carboxypeptidase A
 IPR008969  Carboxypeptidase-like, regulatory domain superfamily
 IPR034232  Carboxypeptidase E, carboxypeptidase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003214 cardiac left ventricle morphogenesis IMP
 biological_processGO:0006464 cellular protein modification process NAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007218 neuropeptide signaling pathway NAS
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0030070 insulin processing IEA
 biological_processGO:0072657 protein localization to membrane IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030141 secretory granule IBA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043025 neuronal cell body IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097060 synaptic membrane IBA
 molecular_functionGO:0004180 carboxypeptidase activity TAS
 molecular_functionGO:0004181 metallocarboxypeptidase activity IEA
 molecular_functionGO:0004185 serine-type carboxypeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042043 neurexin family protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI


Pathways (from Reactome)
Pathway description
Insulin processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000254647 INS / P01308 / insulin  / reaction






 

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