ENSMUSG00000021999


Mus musculus

Features
Gene ID: ENSMUSG00000021999
  
Biological name :Cpb2
  
Synonyms : Carboxypeptidase B2 / Cpb2 / Q9JHH6
  
Possible biological names infered from orthology : Q96IY4
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D3
Gene start: 75242287
Gene end: 75283555
  
Corresponding Affymetrix probe sets: 10416451 (MoGene1.0st)   1418771_a_at (Mouse Genome 430 2.0 Array)   1432834_at (Mouse Genome 430 2.0 Array)   1432835_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022576
NCBI entrez gene - 56373     See in Manteia.
MGI - MGI:1891837
RefSeq - NM_019775
RefSeq Peptide - NP_062749
swissprot - Q9JHH6
Ensembl - ENSMUSG00000021999
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpb2ENSDARG00000037144Danio rerio
 CPB2ENSGALG00000016985Gallus gallus
 CPB2ENSG00000080618Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cpb1 / carboxypeptidase B1 (tissue) / P15086* / carboxypeptidase B1*ENSMUSG0000001146342
Cpa6 / Q5U901 / Carboxypeptidase A6 / Q8N4T0*ENSMUSG0000004250139
Cpa3 / P15089 / Mast cell carboxypeptidase A / P15088* / carboxypeptidase A3*ENSMUSG0000000186539
Cpa5 / Q8R4H4 / Carboxypeptidase A5 / Q8WXQ8*ENSMUSG0000002978838
Cpa1 / Q7TPZ8 / Carboxypeptidase A1 / P15085*ENSMUSG0000005444638
Cpa4 / Q6P8K8 / Carboxypeptidase A4 / Q9UI42*ENSMUSG0000003907036
Cpa2 / Q504N0 / Carboxypeptidase A2 / P48052*ENSMUSG0000007155336


Protein motifs (from Interpro)
Interpro ID Name
 IPR000834  Peptidase M14, carboxypeptidase A
 IPR003146  Carboxypeptidase, activation peptide
 IPR033849  Carboxypeptidase B2
 IPR036990  Metallocarboxypeptidase-like, propeptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003331 positive regulation of extracellular matrix constituent secretion IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0010757 negative regulation of plasminogen activation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0051918 negative regulation of fibrinolysis IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:2000346 negative regulation of hepatocyte proliferation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0004180 carboxypeptidase activity IDA
 molecular_functionGO:0004181 metallocarboxypeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mtm1tm1.2Jman/Y,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129T1/Sv * C57BL/6 * SJL

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Cpb2tm1Efp/Cpb2+,Plgtm1Dco/Plgtm1Dco
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Cpb2tm1Efp/Cpb2tm1Efp,Plgtm1Dco/Plg+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002472 impaired complement alternative pathway "abnormal function of the plasma protein cascade triggered by direct contact with pathogen surfaces" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mtm1tm1.2Jman/Y,Tg(ACTA1-cre)79Jme/?
Genetic Background: involves: 129T1/Sv * C57BL/6 * SJL

Allelic Composition: Cpb2tm1Efp/Cpb2tm1Efp,Plgtm1Dco/Plgtm1Dco
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Cpb2tm1Efp/Cpb2+,Plgtm1Dco/Plgtm1Dco
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Cpb2tm1Efp/Cpb2+,Plgtm1Dco/Plg+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Cpb2tm1Efp/Cpb2tm1Efp,Plgtm1Dco/Plg+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Cpb2tm1Mng/Cpb2tm1Mng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0003422 abnormal thrombolysis "altered ability to break up (lyse) blood clots that are restricting the blood flow" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:17427]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cpb2tm1Mng/Cpb2tm1Mng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cpb2tm1Mng/Cpb2tm1Mng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Cpb2tm1Mng/Cpb2tm1Mng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Cpb2tm1Mng/Cpb2tm1Mng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cpb2tm1Mng/Cpb2tm1Mng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011502 parietal capsular epithelium metaplasia "a metaplastic change or transformation of the single layer of the parietal epithelium of Bowman s capsule from the normal structural appearance of simple squamous epithelium to a cuboidal or low columnar epithelium; also referred to as a prominent parietal epithelium" [MGI:anna]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / reaction
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction






 

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