ENSG00000080618


Homo sapiens

Features
Gene ID: ENSG00000080618
  
Biological name :CPB2
  
Synonyms : carboxypeptidase B2 / CPB2 / Q96IY4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q14.13
Gene start: 46053195
Gene end: 46105033
  
Corresponding Affymetrix probe sets: 206651_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000496703
Ensembl peptide - ENSP00000181383
Ensembl peptide - ENSP00000400714
NCBI entrez gene - 1361     See in Manteia.
OMIM - 603101
RefSeq - XM_017020393
RefSeq - NM_001278541
RefSeq - NM_001872
RefSeq Peptide - NP_001265470
RefSeq Peptide - NP_001863
swissprot - Q96IY4
swissprot - A0A087WSY5
Ensembl - ENSG00000080618
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpb2ENSDARG00000037144Danio rerio
 CPB2ENSGALG00000016985Gallus gallus
 Cpb2ENSMUSG00000021999Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CPB1 / P15086 / carboxypeptidase B1ENSG0000015300240
CPA3 / P15088 / carboxypeptidase A3ENSG0000016375139
CPA6 / Q8N4T0 / carboxypeptidase A6ENSG0000016507838
CPA2 / P48052 / carboxypeptidase A2ENSG0000015851638
CPA5 / Q8WXQ8 / carboxypeptidase A5ENSG0000015852537
CPA1 / P15085 / carboxypeptidase A1ENSG0000009170437
CPA4 / Q9UI42 / carboxypeptidase A4ENSG0000012851035
CPO / Q8IVL8 / carboxypeptidase OENSG0000014441034


Protein motifs (from Interpro)
Interpro ID Name
 IPR000834  Peptidase M14, carboxypeptidase A
 IPR003146  Carboxypeptidase, activation peptide
 IPR033849  Carboxypeptidase B2
 IPR036990  Metallocarboxypeptidase-like, propeptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003331 positive regulation of extracellular matrix constituent secretion IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0010757 negative regulation of plasminogen activation IEA
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0051918 negative regulation of fibrinolysis IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:2000346 negative regulation of hepatocyte proliferation IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004180 carboxypeptidase activity IEA
 molecular_functionGO:0004181 metallocarboxypeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000125730 C3 / P01024 / complement C3  / reaction
 ENSG00000106804 C5 / P01031 / complement C5  / reaction






 

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