ENSG00000091704


Homo sapiens

Features
Gene ID: ENSG00000091704
  
Biological name :CPA1
  
Synonyms : carboxypeptidase A1 / CPA1 / P15085
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q32.2
Gene start: 130380339
Gene end: 130388114
  
Corresponding Affymetrix probe sets: 205615_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419408
Ensembl peptide - ENSP00000475021
Ensembl peptide - ENSP00000420218
Ensembl peptide - ENSP00000419497
Ensembl peptide - ENSP00000011292
NCBI entrez gene - 1357     See in Manteia.
OMIM - 114850
RefSeq - NM_001868
RefSeq Peptide - NP_001859
swissprot - C9JUF9
swissprot - C9JQ63
swissprot - C9JUZ4
swissprot - P15085
swissprot - S4R433
Ensembl - ENSG00000091704
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpa1ENSDARG00000030915Danio rerio
 cpa5ENSDARG00000021339Danio rerio
 CPA1ENSGALG00000008087Gallus gallus
 Cpa1ENSMUSG00000054446Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CPA2 / P48052 / carboxypeptidase A2ENSG0000015851662
CPA5 / Q8WXQ8 / carboxypeptidase A5ENSG0000015852560
CPA4 / Q9UI42 / carboxypeptidase A4ENSG0000012851054
CPB1 / P15086 / carboxypeptidase B1ENSG0000015300242
CPB2 / Q96IY4 / carboxypeptidase B2ENSG0000008061837
CPA6 / Q8N4T0 / carboxypeptidase A6ENSG0000016507837
CPA3 / P15088 / carboxypeptidase A3ENSG0000016375137
CPO / Q8IVL8 / carboxypeptidase OENSG0000014441030


Protein motifs (from Interpro)
Interpro ID Name
 IPR000834  Peptidase M14, carboxypeptidase A
 IPR003146  Carboxypeptidase, activation peptide
 IPR034248  Carboxypeptidase A, carboxypeptidase domain
 IPR036990  Metallocarboxypeptidase-like, propeptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0004180 carboxypeptidase activity IEA
 molecular_functionGO:0004181 metallocarboxypeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008238 exopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000819 Diabetes mellitus 
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 HP:0000952 Jaundice "Yellow pigmentation of the skin or sclera due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream." [HPO:curators]
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 HP:0001974 Leukocytosis "An abnormal increase in the number of `leukocytes` (CL:0000738) in the `blood` (FMA:9670)." [HPO:probinson]
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 HP:0002027 Abdominal pain 
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 HP:0005213 Pancreatic calcification 
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 HP:0011227 Elevated C-reactive protein level "An abnormal elevation of the C-reactive protein level in serum." [HPO:probinson]
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 HP:0012379 Abnormal enzyme/coenzyme activity "An altered ability of any enzyme or their cofactors to act as catalysts." [HPO:probinson, MP:0005584]
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 HP:0030247 Splanchnic vein thrombosis "The term splanchnic vein thrombosis encompasses Budd-Chiari syndrome (hepatic vein thrombosis), extrahepatic portal vein obstruction (EHPVO), and mesenteric vein thrombosis; the word splanchnic is used to refer to the visceral organs (of the abdominal cavity)." [HPO:probinson, pmid:20532730]
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 HP:0100027 Recurrent pancreatitis "A `recurrent` (PATO:0000427) form of `pancreatitis` (HP:0001733)." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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