ENSMUSG00000001865


Mus musculus

Features
Gene ID: ENSMUSG00000001865
  
Biological name :Cpa3
  
Synonyms : Cpa3 / Mast cell carboxypeptidase A / P15089
  
Possible biological names infered from orthology : carboxypeptidase A3 / P15088
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A2
Gene start: 20215620
Gene end: 20242181
  
Corresponding Affymetrix probe sets: 10497451 (MoGene1.0st)   1448730_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001921
NCBI entrez gene - 12873     See in Manteia.
MGI - MGI:88479
RefSeq - XM_006535382
RefSeq - NM_007753
RefSeq Peptide - NP_031779
swissprot - P15089
swissprot - Q542E3
Ensembl - ENSMUSG00000001865
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpb1ENSDARG00000045442Danio rerio
 CPA3ENSG00000163751Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cpb1 / carboxypeptidase B1 (tissue) / P15086* / carboxypeptidase B1*ENSMUSG0000001146348
Cpa6 / Q5U901 / Carboxypeptidase A6 / Q8N4T0*ENSMUSG0000004250142
Cpb2 / Q9JHH6 / Carboxypeptidase B2 / Q96IY4*ENSMUSG0000002199940
Cpa1 / Q7TPZ8 / Carboxypeptidase A1 / P15085*ENSMUSG0000005444639
Cpa4 / Q6P8K8 / Carboxypeptidase A4 / Q9UI42*ENSMUSG0000003907038
Cpa2 / Q504N0 / Carboxypeptidase A2 / P48052*ENSMUSG0000007155337
Cpa5 / Q8R4H4 / Carboxypeptidase A5 / Q8WXQ8*ENSMUSG0000002978837


Protein motifs (from Interpro)
Interpro ID Name
 IPR000834  Peptidase M14, carboxypeptidase A
 IPR003146  Carboxypeptidase, activation peptide
 IPR036990  Metallocarboxypeptidase-like, propeptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002002 regulation of angiotensin levels in blood IGI
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0004180 carboxypeptidase activity IEA
 molecular_functionGO:0004181 metallocarboxypeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cpa3tm1Hrr/Cpa3tm1Hrr
Genetic Background: B6.129P2-Cpa3tm1Hrr

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0008758 abnormal T cell receptor beta chain V(D)J recombination "any anomaly in the process by which V, D, and J segments of the T cell receptor beta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cpa3tm1Hrr/Cpa3tm1Hrr
Genetic Background: B6.129P2-Cpa3tm1Hrr

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cpa3tm1Hrr/Cpa3tm1Hrr
Genetic Background: B6.129P2-Cpa3tm1Hrr

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cpa3tm1Hrr/Cpa3tm1Hrr
Genetic Background: B6.129P2-Cpa3tm1Hrr

 MP:0011696 absent mast cells "any structural anomaly of a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation; progenitors leave bone marrow and mature in connective and mucosal tissue; mature mast cells are found in all tissues, except the bloodstream." [CL:0000097]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031980 Agt / angiotensinogen / P01019*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr