ENSGALG00000006992


Gallus gallus

Features
Gene ID: ENSGALG00000006992
  
Biological name :MMP9
  
Synonyms : matrix metalloproteinase-9 precursor / MMP9
  
Possible biological names infered from orthology : matrix metallopeptidase 9 / Matrix metalloproteinase-9 / P14780 / P41245
  
Species: Gallus gallus
  
Chr. number: 20
Strand: 1
Band:
Gene start: 10773802
Gene end: 10777893
  
Corresponding Affymetrix probe sets: Gga.198.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000011309
NCBI entrez gene - 395387     See in Manteia.
RefSeq - NM_204667
RefSeq Peptide - NP_989998
swissprot - F1NGT3
Ensembl - ENSGALG00000006992
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp9ENSDARG00000042816Danio rerio
 MMP9ENSG00000100985Homo sapiens
 Mmp9ENSMUSG00000017737Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP2 / Q90611 / 72 kDa type IV collagenase / P08253* / P33434* / matrix metallopeptidase 2* / 72 kDa type IV collagenase PEX*ENSGALG0000000358046
MMP28 / matrix metallopeptidase 28 / Q9H239* / matrix metallopeptidase 28 (epilysin)*ENSGALG0000000208122
MMP23B / matrix metallopeptidase 23B / Mmp23* / O75900* / O88676* / Matrix metalloproteinase-23 Matrix metalloproteinase-23, soluble form*ENSGALG0000000139213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000562  Fibronectin type II domain
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR013806  Kringle-like fold
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028688  Matrix metalloproteinase-9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0051549 positive regulation of keratinocyte migration IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:1900122 positive regulation of receptor binding IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA
 biological_processGO:2001258 negative regulation of cation channel activity IEA
 biological_processGO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000608 CDH1 / cadherin 1 / P12830*  / reaction
 ENSGALG00000011206 KITLG / Q09108 / Kit ligand Processed kit ligand / Kitl* / P20826* / P21583* / KIT ligand* / Kit ligand Soluble KIT ligand*  / reaction
 ENSGALG00000019061 MMP1* / MMP8* / Mmp1b* / Mmp1a* / P22894* / P03956* / O70138* / Neutrophil collagenase * / matrix metallopeptidase 1* / matrix metallopeptidase 8* / interstitial collagenase A preproprotein *  / reaction
 ENSGALG00000039080 CD44 / CD44 molecule (Indian blood group) / P16070*  / complex / reaction






 

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