ENSGALG00000006379


Gallus gallus

Features
Gene ID: ENSGALG00000006379
  
Biological name :SHH
  
Synonyms : SHH / sonic hedgehog protein precursor
  
Possible biological names infered from orthology : Q15465 / Q62226 / sonic hedgehog / Sonic hedgehog protein Sonic hedgehog protein N-product
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 8112394
Gene end: 8122029
  
Corresponding Affymetrix probe sets: Gga.345.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000010292
NCBI entrez gene - 395615     See in Manteia.
RefSeq - NM_204821
RefSeq Peptide - NP_990152
swissprot - F1P3J4
Ensembl - ENSGALG00000006379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SHHENSG00000164690Homo sapiens
 ShhENSMUSG00000002633Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IHH / Q98938 / Indian hedgehog protein Indian hedgehog protein N-product Indian hedgehog protein C-product / P97812* / Q14623* / indian hedgehog*ENSGALG0000001134761
DHH / desert hedgehog / O43323* / Q61488* / Desert hedgehog protein Desert hedgehog protein N-product Desert hedgehog protein C-product*ENSGALG0000003170737


Protein motifs (from Interpro)
Interpro ID Name
 IPR000320  Hedgehog, N-terminal signalling domain
 IPR001657  Hedgehog protein
 IPR001767  Hedgehog protein, Hint domain
 IPR003586  Hint domain C-terminal
 IPR003587  Hint domain N-terminal
 IPR006141  Intein N-terminal splicing region
 IPR009045  Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
 IPR028992  Hedgehog/Intein (Hint) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001708 cell fate specification IEA
 biological_processGO:0001709 cell fate determination NAS
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001895 retina homeostasis IMP
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0001944 vasculature development IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002052 positive regulation of neuroblast proliferation IEA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IEA
 biological_processGO:0002076 osteoblast development IEA
 biological_processGO:0002320 lymphoid progenitor cell differentiation IEA
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IEA
 biological_processGO:0003406 retinal pigment epithelium development IMP
 biological_processGO:0003408 optic cup formation involved in camera-type eye development IMP
 biological_processGO:0003430 growth plate cartilage chondrocyte growth IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007228 positive regulation of hh target transcription factor activity IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0007398 ectoderm development IEA
 biological_processGO:0007405 neuroblast proliferation IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007442 hindgut morphogenesis IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0008209 androgen metabolic process IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0009888 tissue development IMP
 biological_processGO:0009949 polarity specification of anterior/posterior axis IEA
 biological_processGO:0009951 polarity specification of dorsal/ventral axis NAS
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IEA
 biological_processGO:0010463 mesenchymal cell proliferation IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0014706 striated muscle tissue development IEA
 biological_processGO:0014858 positive regulation of skeletal muscle cell proliferation IEA
 biological_processGO:0014902 myotube differentiation IEA
 biological_processGO:0016539 intein-mediated protein splicing IEA
 biological_processGO:0021508 floor plate formation IMP
 biological_processGO:0021513 spinal cord dorsal/ventral patterning IMP
 biological_processGO:0021522 spinal cord motor neuron differentiation IEA
 biological_processGO:0021631 optic nerve morphogenesis IMP
 biological_processGO:0021794 thalamus development IEA
 biological_processGO:0021871 forebrain regionalization IEA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0021924 cell proliferation in external granule layer IEA
 biological_processGO:0021930 cerebellar granule cell precursor proliferation IEA
 biological_processGO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IEA
 biological_processGO:0021940 positive regulation of cerebellar granule cell precursor proliferation IEA
 biological_processGO:0021978 telencephalon regionalization IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0030162 regulation of proteolysis IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0030323 respiratory tube development IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IMP
 biological_processGO:0030539 male genitalia development IEA
 biological_processGO:0030850 prostate gland development IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0030902 hindbrain development IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0031069 hair follicle morphogenesis IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus IEA
 biological_processGO:0033092 positive regulation of immature T cell proliferation in thymus IEA
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0035115 embryonic forelimb morphogenesis IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0042481 regulation of odontogenesis IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IEA
 biological_processGO:0043588 skin development IEA
 biological_processGO:0045059 positive thymic T cell selection IEA
 biological_processGO:0045060 negative thymic T cell selection IEA
 biological_processGO:0045109 intermediate filament organization IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045445 myoblast differentiation IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IEA
 biological_processGO:0046639 negative regulation of alpha-beta T cell differentiation IEA
 biological_processGO:0048468 cell development IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048546 digestive tract morphogenesis IEA
 biological_processGO:0048557 embryonic digestive tract morphogenesis IEA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0048598 embryonic morphogenesis IEA
 biological_processGO:0048617 embryonic foregut morphogenesis IEA
 biological_processGO:0048643 positive regulation of skeletal muscle tissue development IEA
 biological_processGO:0048645 animal organ formation IEA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IEA
 biological_processGO:0048663 neuron fate commitment IEA
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0048856 anatomical structure development IEA
 biological_processGO:0048859 formation of anatomical boundary IEA
 biological_processGO:0048864 stem cell development IEA
 biological_processGO:0048877 homeostasis of number of retina cells IMP
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0051155 positive regulation of striated muscle cell differentiation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060020 Bergmann glial cell differentiation IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060173 limb development IEA
 biological_processGO:0060174 limb bud formation IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060428 lung epithelium development IEA
 biological_processGO:0060438 trachea development IEA
 biological_processGO:0060439 trachea morphogenesis IEA
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IEA
 biological_processGO:0060442 branching involved in prostate gland morphogenesis IEA
 biological_processGO:0060445 branching involved in salivary gland morphogenesis IEA
 biological_processGO:0060447 bud outgrowth involved in lung branching IEA
 biological_processGO:0060458 right lung development IEA
 biological_processGO:0060459 left lung development IEA
 biological_processGO:0060463 lung lobe morphogenesis IEA
 biological_processGO:0060484 lung-associated mesenchyme development IEA
 biological_processGO:0060516 primary prostatic bud elongation IEA
 biological_processGO:0060523 prostate epithelial cord elongation IEA
 biological_processGO:0060573 cell fate specification involved in pattern specification NAS
 biological_processGO:0060591 chondroblast differentiation IMP
 biological_processGO:0060662 salivary gland cavitation IEA
 biological_processGO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis IEA
 biological_processGO:0060684 epithelial-mesenchymal cell signaling IEA
 biological_processGO:0060685 regulation of prostatic bud formation IEA
 biological_processGO:0060738 epithelial-mesenchymal signaling involved in prostate gland development IEA
 biological_processGO:0060768 regulation of epithelial cell proliferation involved in prostate gland development IEA
 biological_processGO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development IEA
 biological_processGO:0060782 regulation of mesenchymal cell proliferation involved in prostate gland development IEA
 biological_processGO:0060783 mesenchymal smoothened signaling pathway involved in prostate gland development IEA
 biological_processGO:0060785 regulation of apoptosis involved in tissue homeostasis IMP
 biological_processGO:0060786 regulation of cell differentiation involved in tissue homeostasis TAS
 biological_processGO:0060840 artery development IEA
 biological_processGO:0060916 mesenchymal cell proliferation involved in lung development IEA
 biological_processGO:0061053 somite development IEA
 biological_processGO:0061075 positive regulation of neural retina development IMP
 biological_processGO:0061189 positive regulation of sclerotome development IEA
 biological_processGO:0071285 cellular response to lithium ion IEA
 biological_processGO:0071679 commissural neuron axon guidance IMP
 biological_processGO:0072001 renal system development IEA
 biological_processGO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090269 fibroblast growth factor production IMP
 biological_processGO:0090370 negative regulation of cholesterol efflux IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0097264 self proteolysis IDA
 biological_processGO:1900180 regulation of protein localization to nucleus IEA
 biological_processGO:1904339 negative regulation of dopaminergic neuron differentiation IEA
 biological_processGO:1905327 tracheoesophageal septum formation IEA
 biological_processGO:2000062 negative regulation of ureter smooth muscle cell differentiation IEA
 biological_processGO:2000063 positive regulation of ureter smooth muscle cell differentiation IEA
 biological_processGO:2000177 regulation of neural precursor cell proliferation IMP
 biological_processGO:2000357 negative regulation of kidney smooth muscle cell differentiation IEA
 biological_processGO:2000358 positive regulation of kidney smooth muscle cell differentiation IEA
 biological_processGO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development IEA
 biological_processGO:2001054 negative regulation of mesenchymal cell apoptotic process IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005113 patched binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005539 glycosaminoglycan binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043237 laminin-1 binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog ligand biogenesis
Release of Hh-Np from the secreting cell
Ligand-receptor interactions
Activation of SMO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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