ENSMUSG00000064325


Mus musculus

Features
Gene ID: ENSMUSG00000064325
  
Biological name :Hhip
  
Synonyms : Hedgehog-interacting protein / Hhip / Q7TN16
  
Possible biological names infered from orthology : Q96QV1
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C1
Gene start: 79965851
Gene end: 80058006
  
Corresponding Affymetrix probe sets: 10579894 (MoGene1.0st)   1421426_at (Mouse Genome 430 2.0 Array)   1437933_at (Mouse Genome 430 2.0 Array)   1438083_at (Mouse Genome 430 2.0 Array)   1455277_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078047
NCBI entrez gene - 15245     See in Manteia.
MGI - MGI:1341847
RefSeq - NM_020259
RefSeq - XM_006530702
RefSeq Peptide - NP_064655
swissprot - Q7TN16
Ensembl - ENSMUSG00000064325
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hhipENSDARG00000060397Danio rerio
 HHIPENSGALG00000009948Gallus gallus
 HHIPENSG00000164161Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hhipl2 / Q9D2G9 / HHIP-like protein 2 / Q6UWX4* / HHIP like 2*ENSMUSG0000005346126
Hhipl1 / Q14DK5 / HHIP-like protein 1 / Q96JK4* / HHIP like 1*ENSMUSG0000002126026


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR011041  Soluble quinoprotein glucose/sorbosone dehydrogenase
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR012938  Glucose/Sorbosone dehydrogenase
 IPR013032  EGF-like, conserved site
 IPR018143  Folate receptor-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0007405 neuroblast proliferation IGI
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IGI
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0016525 negative regulation of angiogenesis NAS
 biological_processGO:0040036 regulation of fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IDA
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097108 hedgehog family protein binding IEA


Pathways (from Reactome)
Pathway description
Ligand-receptor interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Hhiptm1Amc/Hhip+,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0001699 enlarged embryo size "larger proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hhiptm1Amc/Hhip+,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002271 abnormal alveolar duct morphology "any structural anomaly of the conducting tubes leading to the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Hhiptm1Amc/Hhip+,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004979 abnormal neuronal precursor cell number "deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hhiptm1Amc/Hhip+,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0006341 small first branchial arch "reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hhiptm1Amc/Hhip+,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0006343 enlarged first branchial arch "increased size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0011934 abnormal branching involved in pancreas development "any anomaly in the process in which the branches of the developing pancreas are generated and organized" [GO:0061114]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012675 enlarged floor plate "increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [MGI:anna]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0013291 ectopic pancreas "presence of well-developed and normally organized pancreatic tissue lying outside its normal location without any anatomical and vascular continuity with the pancreas proper; although an ectopic pancreas can occur throughout the entire gastrointestinal tract, it is most commonly located in the stomach, duodenum, jejunum or Meckel s diverticulum" [MGI:anna]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002633 Shh / Q62226 / Sonic hedgehog protein Sonic hedgehog protein N-product / Q15465* / sonic hedgehog*  / reaction / complex






 

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