ENSDARG00000060397


Danio rerio

Features
Gene ID: ENSDARG00000060397
  
Biological name :hhip
  
Synonyms : hedgehog interacting protein / hhip
  
Possible biological names infered from orthology : Q7TN16 / Q96QV1
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 35790082
Gene end: 35835863
  
Corresponding Affymetrix probe sets: Dr.6382.1.A1_at (Zebrafish Array)   NM_001080012_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000079486
NCBI entrez gene - 326102     See in Manteia.
RefSeq - NM_001080012
RefSeq Peptide - NP_001073481
swissprot - A7X2Z0
ZFIN ID - ZDB-GENE-030131-4827
Ensembl - ENSDARG00000060397
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HHIPENSGALG00000009948Gallus gallus
 HHIPENSG00000164161Homo sapiens
 HhipENSMUSG00000064325Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:ch211-136a13.1ENSDARG0000006092725
hhipl1 / HHIP-like 1 / Q14DK5* / Q96JK4* / HHIP-like protein 1 *ENSDARG0000006250125
hhipl2 / HHIP-like 2 / Q6UWX4* / Q9D2G9* / HHIP-like protein 2 *ENSDARG0000006000825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR011041  Soluble quinoprotein glucose/sorbosone dehydrogenase
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR012938  Glucose/Sorbosone dehydrogenase
 IPR013032  EGF-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009968 negative regulation of signal transduction IMP
 biological_processGO:0033333 fin development IMP
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IMP
 biological_processGO:0048635 negative regulation of muscle organ development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0031226 intrinsic component of plasma membrane IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0097108 hedgehog family protein binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens quality , abnormal
lens degenerate , abnormal
Show

 ZFA:0000040 median fin fold median fin fold epithelium undulate , abnormal
median fin fold increased size , abnormal
median fin fold undulate , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle quality , abnormal
Show

 ZFA:0000217 inner ear inner ear decreased size , abnormal
inner ear structure , abnormal
inner ear morphology , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000445 optic tectum optic tectum quality , abnormal
Show

 ZFA:0001058 caudal fin caudal fin has extra parts of type lepidotrichium , abnormal
Show

 ZFA:0001069 ventral fin fold ventral fin fold epithelium undulate , abnormal
Show

 ZFA:0001086 muscle pioneer muscle pioneer increased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism decreased size , abnormal
whole organism sterile , abnormal
whole organism decreased length , abnormal
whole organism dwarf-like , abnormal
Show

 ZFA:0001114 head head increased volume , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin increased size , abnormal
pectoral fin quality , abnormal
pectoral fin has extra parts of type lepidotrichium , abnormal
pectoral fin undulate , abnormal
Show

 ZFA:0001162 anal fin anal fin aplastic , abnormal
anal fin absent , abnormal
Show

 ZFA:0001173 dorsal fin dorsal fin has extra parts of type lepidotrichium , abnormal
Show

 ZFA:0001184 pelvic fin pelvic fin has extra parts of type lepidotrichium , abnormal
Show

 ZFA:0001283 pupil pupil size , abnormal
pupil decreased length , abnormal
pupil decreased width , abnormal
pupil quality , abnormal
pupil decreased size , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001554 lepidotrichium lepidotrichium increased amount , abnormal
Show

 ZFA:0001672 dorsolateral septum dorsolateral septum aplastic , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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