ENSG00000164161


Homo sapiens

Features
Gene ID: ENSG00000164161
  
Biological name :HHIP
  
Synonyms : hedgehog interacting protein / HHIP / Q96QV1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q31.21
Gene start: 144646021
Gene end: 144745271
  
Corresponding Affymetrix probe sets: 1556037_s_at (Human Genome U133 Plus 2.0 Array)   223775_at (Human Genome U133 Plus 2.0 Array)   230135_at (Human Genome U133 Plus 2.0 Array)   237466_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296575
Ensembl peptide - ENSP00000408587
NCBI entrez gene - 64399     See in Manteia.
OMIM - 606178
RefSeq - XM_006714288
RefSeq - NM_022475
RefSeq - XM_005263178
RefSeq Peptide - NP_071920
swissprot - Q96QV1
Ensembl - ENSG00000164161
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hhipENSDARG00000060397Danio rerio
 HHIPENSGALG00000009948Gallus gallus
 HhipENSMUSG00000064325Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HHIPL2 / Q6UWX4 / HHIP like 2ENSG0000014351226
HHIPL1 / Q96JK4 / HHIP like 1ENSG0000018221825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR011041  Soluble quinoprotein glucose/sorbosone dehydrogenase
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR012938  Glucose/Sorbosone dehydrogenase
 IPR013032  EGF-like, conserved site
 IPR018143  Folate receptor-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007405 neuroblast proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IEA
 biological_processGO:0009968 negative regulation of signal transduction IDA
 biological_processGO:0040036 regulation of fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IBA
 biological_processGO:0048705 skeletal system morphogenesis ISS
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0060170 ciliary membrane TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097108 hedgehog family protein binding IPI


Pathways (from Reactome)
Pathway description
Ligand-receptor interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164690 SHH / Q15465 / sonic hedgehog  / reaction / complex






 

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