ENSMUSG00000023000


Mus musculus

Features
Gene ID: ENSMUSG00000023000
  
Biological name :Dhh
  
Synonyms : Desert hedgehog protein Desert hedgehog protein N-product Desert hedgehog protein C-product / Dhh / Q61488
  
Possible biological names infered from orthology : desert hedgehog / O43323
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 98891152
Gene end: 98898540
  
Corresponding Affymetrix probe sets: 10432372 (MoGene1.0st)   1422127_at (Mouse Genome 430 2.0 Array)   1434959_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023737
Ensembl peptide - ENSMUSP00000155712
NCBI entrez gene - 13363     See in Manteia.
MGI - MGI:94891
RefSeq - XM_017316427
RefSeq - NM_007857
RefSeq - XM_006520406
RefSeq Peptide - NP_031883
swissprot - Q61488
swissprot - Q544P6
Ensembl - ENSMUSG00000023000
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhhENSDARG00000037062Danio rerio
 DHHENSGALG00000031707Gallus gallus
 DHHENSG00000139549Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Shh / Q62226 / Sonic hedgehog protein Sonic hedgehog protein N-product / Q15465* / sonic hedgehog*ENSMUSG0000000263355
Ihh / P97812 / Indian hedgehog / Q14623*ENSMUSG0000000653853


Protein motifs (from Interpro)
Interpro ID Name
 IPR000320  Hedgehog, N-terminal signalling domain
 IPR001657  Hedgehog protein
 IPR001767  Hedgehog protein, Hint domain
 IPR003586  Hint domain C-terminal
 IPR003587  Hint domain N-terminal
 IPR006141  Intein N-terminal splicing region
 IPR009045  Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
 IPR036844  Hint domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007224 smoothened signaling pathway IDA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0016539 intein-mediated protein splicing IEA
 biological_processGO:0030238 male sex determination IGI
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033327 Leydig cell differentiation IMP
 biological_processGO:0042552 myelination IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0050810 regulation of steroid biosynthetic process IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005113 patched binding IPI
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog ligand biogenesis
Release of Hh-Np from the secreting cell
Ligand-receptor interactions
Activation of SMO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: CaskTg(Bnlf1)1Wln/CaskTg(Bnlf1)1Wln
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0002786 abnormal Leydig cell morphology "malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0002789 male pseudohermaphroditism "pseudohermaphroditism in which the gonads are male (testes) and the karyotype is XY but the secondary sex characteristics are female-like or ambiguous" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: CaskTg(Bnlf1)1Wln/CaskTg(Bnlf1)1Wln
Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005189 abnormal anogenital distance "in comparison to the norm, aberration in the measure of the length of space from the genitals to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0005536 Leydig cell hypoplasia "reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006418 abnormal testis cord formation "any structural anomaly in the formation of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence; defective testis cord formation is most likely to reflect abnormal function of either Sertoli cells or peritubular myoid (PTM) cells which normally cooperate to deposit a layer of basal lamina that defines the edges of individual testis cords" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0006420 abnormal peritubular myoid cell morphology "any structural anomaly of the flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0006421 decreased number of peritubular myoid cells "reduced number of the flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster

 MP:0008279 arrest of spermiogenesis "block in the process by which a spermatid transforms into a functional spermatozoon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhhtm1Amc/Dhhtm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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