ENSMUSG00000024163


Mus musculus

Features
Gene ID: ENSMUSG00000024163
  
Biological name :Mapk8ip3
  
Synonyms : C-Jun-amino-terminal kinase-interacting protein 3 / Mapk8ip3 / Q9ESN9
  
Possible biological names infered from orthology : mitogen-activated protein kinase 8 interacting protein 3 / Q9UPT6
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 24892153
Gene end: 24936977
  
Corresponding Affymetrix probe sets: 10448755 (MoGene1.0st)   10448765 (MoGene1.0st)   1416437_a_at (Mouse Genome 430 2.0 Array)   1425975_a_at (Mouse Genome 430 2.0 Array)   1429034_at (Mouse Genome 430 2.0 Array)   1436676_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114084
Ensembl peptide - ENSMUSP00000114802
Ensembl peptide - ENSMUSP00000136924
Ensembl peptide - ENSMUSP00000118422
Ensembl peptide - ENSMUSP00000085683
Ensembl peptide - ENSMUSP00000110883
Ensembl peptide - ENSMUSP00000110884
Ensembl peptide - ENSMUSP00000112712
Ensembl peptide - ENSMUSP00000112955
Ensembl peptide - ENSMUSP00000113698
Ensembl peptide - ENSMUSP00000113753
NCBI entrez gene - 30957     See in Manteia.
MGI - MGI:1353598
RefSeq - NM_001163449
RefSeq - NM_001163450
RefSeq - NM_001163451
RefSeq - NM_001163453
RefSeq - NM_013931
RefSeq - NM_001163447
RefSeq - NM_001163448
RefSeq Peptide - NP_001156920
RefSeq Peptide - NP_001156922
RefSeq Peptide - NP_001156923
RefSeq Peptide - NP_001156925
RefSeq Peptide - NP_038959
RefSeq Peptide - NP_001156919
RefSeq Peptide - NP_001156921
swissprot - Q9ESN9
swissprot - E9Q6B6
swissprot - J3QNR6
swissprot - K3W4S4
swissprot - D3YWH6
swissprot - Q3UHB5
swissprot - E9Q6E0
Ensembl - ENSMUSG00000024163
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk8ip3ENSDARG00000062531Danio rerio
 Q9UPT6ENSG00000138834Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spag9 / Q58A65 / sperm associated antigen 9 / O60271*ENSMUSG0000002085958
Q80U35 / Arhgef17 / Rho guanine nucleotide exchange factor 17 / Q96PE2*ENSMUSG0000003287522
A2AWP8 / Arhgef10l / Rho guanine nucleotide exchange factor 10-like protein / Q9HCE6* / Rho guanine nucleotide exchange factor 10 like*ENSMUSG0000004096415
Q8C033 / Arhgef10 / Rho guanine nucleotide exchange factor 10 / O15013*ENSMUSG0000007117614


Protein motifs (from Interpro)
Interpro ID Name
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR019143  JNK/Rab-associated protein-1, N-terminal
 IPR027267  AH/BAR domain superfamily
 IPR032486  JNK-interacting protein, leucine zipper II
 IPR034743  RH1 domain
 IPR034744  RH2 domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0007254 JNK cascade IDA
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0016192 vesicle-mediated transport IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0046328 regulation of JNK cascade IDA
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0060425 lung morphogenesis IMP
 cellular_componentGO:0000139 Golgi membrane IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0030673 axolemma IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0005078 MAP-kinase scaffold activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008432 JUN kinase binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019894 kinesin binding IPI
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IBA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IPI
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000792 abnormal cortical marginal zone morphology 
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000794 abnormal parietal lobe morphology "malformation or absence of the upper central part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000798 abnormal frontal lobe morphology "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Fasltm1.1Cgm/Fasltm1.1Cgm
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

 MP:0001179 thicker alveolar septa 
Show

Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mapk8ip3tm1Plhn/Mapk8ip3tm1Plhn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

Allelic Composition: Mapk8ip3tm1Plhn/Mapk8ip3tm1Plhn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

 MP:0002316 anoxia "absence or almost complete absence of oxygen from inspired gases, blood, or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

 MP:0003005 abnormal hippocampal fimbria "malformations in the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk8ip3tm1Plhn/Mapk8ip3tm1Plhn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004267 abnormal optic tract morphology "any structural anomaly of the band of optic nerve fibers running from the optic chiasma to the lateral geniculate body and midbrain" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008219 abnormal dorsal telencephalic commissure morphology "any structural anomaly of the fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure" [PMID:16715082]
Show

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mapk8ip3tm1.1Ysok/Mapk8ip3tm1.1Ysok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008440 abnormal subplate morphology "any strucutral anomaly of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8210173]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008441 thin cortical plate "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk8ip3tm1Plhn/Mapk8ip3tm1Plhn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010859 abnormal anterior commissure pars anterior morphology "any structural anomaly of the small horseshoe-shaped anterior part of the anterior commissure which pass into the two olfactory bulbs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010860 abnormal anterior commissure pars posterior morphology "any structural anomaly of the large posterior part of the anterior commissure which connects the right and left temporal lobes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Mapk8ip3tm1.1Ysok/Mapk8ip3tm1.1Ysok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mapk8ip3tm1Plhn/Mapk8ip3tm1Plhn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0020546 increased hippocampal fornix size "increased size of the hippocampal fornix" [MGI:smb]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0020549 increased optic chiasm size "increased size of the optic chiasm" [MGI:smb]
Show

Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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