ENSMUSG00000020167


Mus musculus

Features
Gene ID: ENSMUSG00000020167
  
Biological name :Tcf3
  
Synonyms : P15806 / Tcf3 / Transcription factor E2-alpha
  
Possible biological names infered from orthology : P15923 / transcription factor 3
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 80409514
Gene end: 80433647
  
Corresponding Affymetrix probe sets: 10370837 (MoGene1.0st)   1426297_at (Mouse Genome 430 2.0 Array)   1427764_a_at (Mouse Genome 430 2.0 Array)   1452542_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100977
Ensembl peptide - ENSMUSP00000100976
Ensembl peptide - ENSMUSP00000100978
Ensembl peptide - ENSMUSP00000121172
Ensembl peptide - ENSMUSP00000120303
Ensembl peptide - ENSMUSP00000100983
Ensembl peptide - ENSMUSP00000100982
Ensembl peptide - ENSMUSP00000100981
Ensembl peptide - ENSMUSP00000100980
Ensembl peptide - ENSMUSP00000100979
Ensembl peptide - ENSMUSP00000020377
Ensembl peptide - ENSMUSP00000020379
NCBI entrez gene - 21423     See in Manteia.
MGI - MGI:98510
RefSeq - NM_001164150
RefSeq - NM_001164147
RefSeq - NM_001164148
RefSeq - NM_001164149
RefSeq - NM_001164151
RefSeq - NM_001164152
RefSeq - NM_001164153
RefSeq - NM_011548
RefSeq - XM_017313871
RefSeq - XM_017313872
RefSeq - XM_017313873
RefSeq - XM_017313874
RefSeq Peptide - NP_001157623
RefSeq Peptide - NP_001157624
RefSeq Peptide - NP_001157625
RefSeq Peptide - NP_035678
RefSeq Peptide - NP_001157619
RefSeq Peptide - NP_001157620
RefSeq Peptide - NP_001157621
RefSeq Peptide - NP_001157622
swissprot - E9PWE5
swissprot - E9PWE4
swissprot - E9PWE3
swissprot - E9PWE2
swissprot - A0A0R4J011
swissprot - E9PVV2
swissprot - E9PVV1
swissprot - D3Z037
swissprot - P15806
swissprot - F6T941
swissprot - A0A0R4J014
Ensembl - ENSMUSG00000020167
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tcf3aENSDARG00000005915Danio rerio
 tcf3bENSDARG00000099999Danio rerio
 TCF3ENSGALG00000001093Gallus gallus
 TCF3ENSG00000071564Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tcf12 / Q61286 / transcription factor 12 / Q99081*ENSMUSG0000003222850
Tcf4 / Q60722 / transcription factor 4 / P15884*ENSMUSG0000005347748


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001779 natural killer cell differentiation IGI
 biological_processGO:0002326 B cell lineage commitment ISO
 biological_processGO:0006351 transcription, DNA-templated ISO
 biological_processGO:0006355 regulation of transcription, DNA-templated IGI
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007369 gastrulation IGI
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030098 lymphocyte differentiation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030890 positive regulation of B cell proliferation ISO
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0033152 immunoglobulin V(D)J recombination ISO
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0043966 histone H3 acetylation IMP
 biological_processGO:0043967 histone H4 acetylation IMP
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045787 positive regulation of cell cycle ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048468 cell development IGI
 biological_processGO:0048541 Peyer"s patch development IGI
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISS
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle ISO
 cellular_componentGO:0000788 nuclear nucleosome IDA
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IMP
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043425 bHLH transcription factor binding IBA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070491 repressing transcription factor binding ISO
 molecular_functionGO:0070644 vitamin D response element binding ISO
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
CDO in myogenesis
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

 MP:0000238 deficiency of pre-B cells "lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0000516 abnormal urinary system morphology "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N)

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf3tm1Zhu/Tcf3tm2Zhu
Genetic Background: involves: 129 * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Id3tm2.1Cmu/Id3tm2.1Cmu
Genetic Background: Not Specified

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Pax1un/Pax1+,Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tcf3tm6(Esr1*)Zhu/Tcf3tm6(Esr1*)Zhu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Tcf4tm1Zhu/Tcf4+,Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tcf3tm2Wein/Tcf3tm2Wein
Genetic Background: Not Specified

Allelic Composition: Tcf3tm6(Esr1*)Zhu/Tcf3tm6(Esr1*)Zhu
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Tcf3tm3.1Cmu/Tcf3tm3.1Cmu
Genetic Background: involves: 129S/SvEv * FVB/N

Allelic Composition: Tcf3tm6(Esr1*)Zhu/Tcf3tm6(Esr1*)Zhu
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Ightm2Cgn/Igh+,Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129 * C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Pax1un/Pax1+,Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Tcf3tm2Wein/Tcf3tm2Wein
Genetic Background: Not Specified

Allelic Composition: Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
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Allelic Composition: Tcf3tm1(TCF3/HLF)Homy/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tcf3tm2Wein/Tcf3tm2Wein
Genetic Background: Not Specified

Allelic Composition: Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Tcf3tm1(TCF3/HLF)Homy/Tcf3+,Tg(Emu-Zfp521)#Homy/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf3tm1Zhu/Tcf3tm2Zhu
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax1un/Pax1+,Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Tcf3tm2Wein/Tcf3tm2Wein
Genetic Background: Not Specified

Allelic Composition: Tcf3tm6(Esr1*)Zhu/Tcf3tm6(Esr1*)Zhu
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Tcf3tm2Zhu/Tcf3tm2Zhu
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Tcf3tm1(TCF3/HLF)Homy/Tcf3+,Tg(Emu-Zfp521)#Homy/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Tcf3tm3.1Cmu/Tcf3tm3.1Cmu
Genetic Background: involves: 129S/SvEv * FVB/N

Allelic Composition: Tcf3tm1(TCF3/HLF)Homy/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Pax1un/Pax1+,Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Tcf3tm5Zhu/Tcf3tm5Zhu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tcf3tm5.1Cmu/Tcf3tm5.1Cmu
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf3tm1Zhu/Tcf3tm2Zhu
Genetic Background: involves: 129 * C57BL/6

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf3tm1Cmu/Tcf3+
Genetic Background: either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N)

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pax1un/Pax1+,Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Pax1un/Pax1+,Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N)

Allelic Composition: Pax1un/Pax1+,Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129

Allelic Composition: Tcf3tm2Zhu/Tcf3tm2Zhu
Genetic Background: involves: 129 * C57BL/6

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

Allelic Composition: Tcf3tm1(TCF3/HLF)Homy/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf3tm1Cmu/Tcf3+
Genetic Background: either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N)

Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcc6rs32756904-T/Abcc6rs32756904-T,Dyscalc2C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf3tm1Cmu/Tcf3+
Genetic Background: either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N)

Allelic Composition: Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N)

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129

Allelic Composition: Tcf3tm1Zhu/Tcf3tm2Zhu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tcf3tm3Zhu/Tcf3tm3Zhu
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tcf3tm1Mbu/Tcf3tm1.2Mbu,Tg(Fcer2a-cre)5Mbu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Tcf3tm1Mbu/Tcf3tm1.2Mbu,Tg(Aicda-cre)9Mbu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL/J

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf3tm1(TCF3/HLF)Homy/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL/J

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129 * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL/J

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129 * C57BL/6J

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL/J

 MP:0005432 abnormal pro-B cell "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/NJ)

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf3tm3.1Cmu/Tcf3tm3.1Cmu
Genetic Background: involves: 129S/SvEv * FVB/N

Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129 * C57BL/6J

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0008176 abnormal germinal center B cell morphology "any structural anomaly of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf3tm1Mbu/Tcf3tm1.2Mbu,Tg(Fcer2a-cre)5Mbu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Tcf3tm1Mbu/Tcf3tm1.2Mbu,Tg(Aicda-cre)9Mbu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Tcf3tm1Mbu/Tcf3tm1.2Mbu,Tg(Fcer2a-cre)5Mbu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Tcf3tm1Mbu/Tcf3tm1.2Mbu,Tg(Aicda-cre)9Mbu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Tcf3tm1Mbu/Tcf3tm1.2Mbu,Tg(Fcer2a-cre)5Mbu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

 MP:0008187 absent pro-B cells "absence of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Tcf4tm1Zhu/Tcf4+,Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tcf3tm2Zhu/Tcf3tm2Zhu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tcf3tm1Wein/Tcf3tm3Zhu
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Tcf3tm1Mbu/Tcf3tm1Mbu,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tcf3tm4.1Cmu/Tcf3tm4.1Cmu
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Tcf3tm2Zhu/Tcf3tm2Zhu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu,Tg(Vav-BCL2)1Jad/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tcf3tm3.1Cmu/Tcf3tm3.1Cmu
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008233 abnormal pro-B cell differentiation "atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008755 abnormal immunoglobulin V(D)J recombination "any anomaly in the process by which immunoglobulin V, D, and J or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033152, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N)

 MP:0008760 abnormal immunoglobulin heavy chain V(D)J recombination "any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N)

Allelic Composition: Ikzf1tm1.1(Pax5)Mbu/Ikzf1+,Tcf3tm1Mbu/Tcf3tm1Mbu,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca

Allelic Composition: Tcf3tm6(Esr1*)Zhu/Tcf3tm6(Esr1*)Zhu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008761 abnormal immunoglobulin light chain V-J recombination "any anomaly in the process by which V and J gene segments of the immunoglobulin light chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf3tm3.1Cmu/Tcf3tm3.1Cmu
Genetic Background: involves: 129S/SvEv * FVB/N

Allelic Composition: Tcf3tm4.1Cmu/Tcf3tm4.1Cmu
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0009622 absent inguinal lymph nodes "absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009628 absent brachial lymph nodes "absence of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009630 absent axillary lymph nodes "absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf3tm1(TCF3/HLF)Homy/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Tcf4tm1Zhu/Tcf4+,Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N)

Allelic Composition: Pax1un/Pax1+,Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Tcf3tm1Wein/Tcf3tm3Zhu
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0014050 increased B cell acute lymphoblastic leukemia incidence "an aggressive (fast-growing) type of leukemia (blood cancer) in which too many B-cell lymphoblasts (immature white blood cells) are found in the bone marrow and blood; it is the most common type of acute lymphoblastic leukemia (ALL)" [NCIT:C8644]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000435 Myf5 / P24699 / Myogenic factor 5 / P13349*  / complex
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / reaction
 ENSMUSG00000030557 Mef2a / Q60929 / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA. / Q02078* / myocyte enhancer factor 2A*  / reaction / complex
 ENSMUSG00000005583 Mef2c / Q8CFN5 / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA. / Q06413* / myocyte enhancer factor 2C*  / reaction / complex
 ENSMUSG00000026459 Myog / P12979 / Myogenin / P15173*  / complex
 ENSMUSG00000035923 Myf6 / P15375 / Myogenic factor 6 / P23409*  / complex
 ENSMUSG00000009471 Myod1 / P10085 / Myoblast determination protein 1 / P15172* / myogenic differentiation 1*  / reaction / complex
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / reaction






 

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