ENSMUSG00000009471


Mus musculus

Features
Gene ID: ENSMUSG00000009471
  
Biological name :Myod1
  
Synonyms : Myoblast determination protein 1 / Myod1 / P10085
  
Possible biological names infered from orthology : myogenic differentiation 1 / P15172
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 46376474
Gene end: 46379099
  
Corresponding Affymetrix probe sets: 10553256 (MoGene1.0st)   1418420_at (Mouse Genome 430 2.0 Array)   1447675_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072330
NCBI entrez gene - 17927     See in Manteia.
MGI - MGI:97275
RefSeq - NM_010866
RefSeq Peptide - NP_034996
swissprot - P10085
Ensembl - ENSMUSG00000009471
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myod1ENSDARG00000030110Danio rerio
 MYOD1ENSGALG00000006216Gallus gallus
 MYOD1ENSG00000129152Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myf5 / P24699 / Myogenic factor 5 / P13349*ENSMUSG0000000043540
Myf6 / P15375 / Myogenic factor 6 / P23409*ENSMUSG0000003592330
Myog / P12979 / Myogenin / P15173*ENSMUSG0000002645924


Protein motifs (from Interpro)
Interpro ID Name
 IPR002546  Myogenic basic muscle-specific protein
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR022032  Myogenic determination factor 5
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IGI
 biological_processGO:0007518 myoblast fate determination IDA
 biological_processGO:0007519 skeletal muscle tissue development TAS
 biological_processGO:0007520 myoblast fusion IMP
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0014902 myotube differentiation IDA
 biological_processGO:0014904 myotube cell development IEA
 biological_processGO:0014908 myotube differentiation involved in skeletal muscle regeneration IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035914 skeletal muscle cell differentiation NAS
 biological_processGO:0043415 positive regulation of skeletal muscle tissue regeneration IMP
 biological_processGO:0043484 regulation of RNA splicing IEA
 biological_processGO:0043503 skeletal muscle fiber adaptation IMP
 biological_processGO:0043966 histone H3 acetylation IDA
 biological_processGO:0043967 histone H4 acetylation IDA
 biological_processGO:0045445 myoblast differentiation IDA
 biological_processGO:0045663 positive regulation of myoblast differentiation IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0048743 positive regulation of skeletal muscle fiber development IBA
 biological_processGO:0051146 striated muscle cell differentiation IMP
 biological_processGO:0051149 positive regulation of muscle cell differentiation IDA
 biological_processGO:0055007 cardiac muscle cell differentiation NAS
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IDA
 biological_processGO:0071392 cellular response to estradiol stimulus IDA
 biological_processGO:0071453 cellular response to oxygen levels IDA
 biological_processGO:1901741 positive regulation of myoblast fusion IEA
 biological_processGO:2000818 negative regulation of myoblast proliferation IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030016 myofibril IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding TAS
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
Show

Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myf5tm1Pas/Myf5tm1Pas
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Myf5tm1Tajb/Myf5tm1Tajb,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf5tm3(cre)Sor/Myf5tm3(cre)Sor,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myog+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Abl1tm1Gcos/Abl1+,Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6tm1Tajb,Myod1tm2.1(icre)Glh/Myod1+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J

 MP:0000730 increased number of satellite cells "greater number of unfused cells in muscle that play a role in muscle regeneration" [J:42574]
Show

Allelic Composition: Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scn8anur14/Scn8anur14
Genetic Background: involves: C57BL/6J

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf5tm1Jae/Myf5tm1Jae,Myod1tm1.1Glh/Myod1tm1.1Glh
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Myf5tm1Jae/Myf5tm1Jae,Myod1tm1.1Glh/Myod1+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
Show

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(KRT5-cre/PGR)1Der/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB * ICR

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Krastm4Tyj/Kras+,Myod1tm1.1(cre/ERT,TVA)Gcg/Myod1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Krastm4Tyj/Kras+,Myod1tm1.1(cre/ERT,TVA)Gcg/Myod1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myf5tm1Pas/Myf5tm1Pas
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Myf5tm1Pas/Myf5+,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdmdx/?,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1+,Myogtm1Whk/Myog+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myod1tm2Glh/Myod1tm2Glh
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Myod1tm2.1Glh/Myod1tm2.1Glh
Genetic Background: involves: 129 * C57BL/6J

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dmdmdx/?,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dmdmdx/?,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdmdx/?,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0003833 decreased number of satellite cells "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myf5tm1(cre)Mrc/Myf5+,Myod1tm1Jae/Myod1tm1Jae,Pax7tm1.1Thbr/Pax7tm1.1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/?,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0004846 absent skeletal muscle "absence of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myf5tm1Pas/Myf5tm1Pas
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Myf5tm1Tajb/Myf5tm1Tajb,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmdmdx/?,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dmdmdx/?,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Dmdmdx/?,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Abl1tm1Gcos/Abl1+,Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6tm1Tajb,Myod1tm2.1(icre)Glh/Myod1+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Myf5tm1Pas/Myf5tm1Pas
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Myf5tm1Tajb/Myf5tm1Tajb,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0013237 abnormal skeletal muscle regeneration "anomaly in the ability to repair skeletal muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020167 Tcf3 / P15806 / Transcription factor E2-alpha / P15923* / transcription factor 3*  / complex / reaction
 ENSMUSG00000030557 Mef2a / Q60929 / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA. / Q02078* / myocyte enhancer factor 2A*  / reaction / complex
 ENSMUSG00000005583 Mef2c / Q8CFN5 / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA. / Q06413* / myocyte enhancer factor 2C*  / complex / reaction






 

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