ENSMUSG00000000435


Mus musculus

Features
Gene ID: ENSMUSG00000000435
  
Biological name :Myf5
  
Synonyms : Myf5 / Myogenic factor 5 / P24699
  
Possible biological names infered from orthology : P13349
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D1
Gene start: 107482908
Gene end: 107486134
  
Corresponding Affymetrix probe sets: 10372226 (MoGene1.0st)   1420757_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000445
NCBI entrez gene - 17877     See in Manteia.
MGI - MGI:97252
RefSeq - XM_006513319
RefSeq - NM_008656
RefSeq Peptide - NP_032682
swissprot - P24699
swissprot - A2RSK4
Ensembl - ENSMUSG00000000435
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myf5ENSDARG00000007277Danio rerio
 MYF5ENSGALG00000028091Gallus gallus
 MYF5ENSG00000111049Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myod1 / P10085 / Myoblast determination protein 1 / P15172* / myogenic differentiation 1*ENSMUSG0000000947150
Myf6 / P15375 / Myogenic factor 6 / P23409*ENSMUSG0000003592336
Myog / P12979 / Myogenin / P15173*ENSMUSG0000002645933


Protein motifs (from Interpro)
Interpro ID Name
 IPR002546  Myogenic basic muscle-specific protein
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR022032  Myogenic determination factor 5
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001502 cartilage condensation IMP
 biological_processGO:0001503 ossification IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001952 regulation of cell-matrix adhesion IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IMP
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0045663 positive regulation of myoblast differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048644 muscle organ morphogenesis IGI
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0048743 positive regulation of skeletal muscle fiber development IBA
 biological_processGO:0060415 muscle tissue morphogenesis IMP
 biological_processGO:1901741 positive regulation of myoblast fusion IBA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding TAS
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Pax3tm1.1Sjc/Pax3tm1.2Sjc
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Myf5tm2(Pdgfa)Sor/Myf5tm2(Pdgfa)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Eno/Myf6+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1.1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Tg(ACTB-Edn1)1398Clou/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Tg(ACTB-Edn1)1408Clou/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Tg(ACTB-Edn1)1416Clou/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Pax3tm1.1Sjc/Pax3tm1.2Sjc
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Myf5tm2(Pdgfa)Sor/Myf5tm2(Pdgfa)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myf5tm1Pas/Myf5tm1Pas
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Myf5tm1Tajb/Myf5tm1Tajb,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf5tm3(cre)Sor/Myf5tm3(cre)Sor,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abl1tm1Gcos/Abl1+,Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6tm1Tajb,Myod1tm2.1(icre)Glh/Myod1+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000731 increased collagen deposition in the muscles "accumulation of collagen within the muscles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Myf5tm1Jae/Myf5tm1Jae,Myod1tm1.1Glh/Myod1tm1.1Glh
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Myf5tm1Jae/Myf5tm1Jae,Myod1tm1.1Glh/Myod1+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Bcl9tm1.1Agt/Bcl9tm1.1Agt,Bcl9ltm1.1Agt/Bcl9ltm1.1Agt,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0000736 delayed muscle development "late onset of the induction and/or differentiation of skeletal muscle" [J:18048]
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Allelic Composition: Lgals1tm1Rob/Lgals1tm1Rob,Myf5tm2Pas/Myf5+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas

 MP:0000737 abnormal myotome development "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Myf5tm2(Myog)Jae/Myf5tm2(Myog)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Myf5tm2(Pdgfa)Sor/Myf5tm2(Pdgfa)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Eno/Myf6+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Myf5tm3.1Thbr/Myf5tm3.1Thbr
Genetic Background: Not Specified

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sortm1(DTA)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: at/at
Genetic Background: Not Specified

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Myf5tm2Pas/Myf5tm2Tajb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Bcl9tm1.1Agt/Bcl9tm1.1Agt,Bcl9ltm1.1Agt/Bcl9ltm1.1Agt,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Myf5tm1Tajb/Myf5tm1Tajb
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Lbx1tm1.1Khan/Lbx1tm1.1Khan,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gdnftm1.1Neas/Gdnftm1.1Neas,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Gfra1tm3Jmi/Gfra1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001038 abnormal cholinergic neuron morphology "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gdnftm1.1Neas/Gdnftm1.1Neas,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Gfra1tm3Jmi/Gfra1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lbx1tm1.1Khan/Lbx1tm1.1Khan,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lin28btm1Gqda/Lin28btm1Gqda,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Pax7tm1.1Thbr/Pax7tm1.1Thbr,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apptm1Ck/Apptm1Ck
Genetic Background: involves: 129

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plekhm2tm1a(EUCOMM)Wtsi/Plekhm2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myf5tm1Pas/Myf5tm1Pas
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Myf5tm1Pas/Myf5+,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129S/SvEv * FVB

Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Myf5tm1(cre/Esr1*)Trdo/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0002253 abnormal pharyngeal muscle morphology "structural anomaly of any of the muscles of the pharynx, the inferior, middle and superior constrictors, salpingopharyngeus, and stylopharyngeus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myf5tm1Tajb/Myf5tm1Tajb,Pax7tm1.1Tajb/Pax7tm1.1Tajb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Myf5tm2Tajb/Myf5+,Tbx1tm1Pa/Tbx1tm1Pa
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Plekhm2tm1a(EUCOMM)Wtsi/Plekhm2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: Myf5tm2(Pdgfa)Sor/Myf5tm2(Pdgfa)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Myf5tm3(cre)Sor/Myf5tm3(cre)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Myf5tm2Pas/Myf5tm2Pas
Genetic Background: involves: 129S2/SvPas

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Sik1tm1.1Berd/Sik1tm1.1Berd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Myf5tm2(Pdgfa)Sor/Myf5tm2(Pdgfa)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lgals1tm1Rob/Lgals1tm1Rob,Myf5tm2Pas/Myf5+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas

 MP:0003090 abnormal muscle progenitor cell migration "defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Myf5tm1Tajb/Myf5tm1Tajb
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Lbx1tm1.1Khan/Lbx1tm1.1Khan,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Sik1tm1.1Berd/Sik1tm1.1Berd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0003794 delayed somite formation "late onset of the induction and/or differentiation of the somites" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99723]
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Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0003818 abnormal eye muscle development "malformation or arrest of differentiation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Myf5tm1Tajb/Myf5tm1Tajb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6tm1Tajb
Genetic Background: involves: 129S2/SvPas

 MP:0003833 decreased number of satellite cells "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Pax7tm1.1Thbr/Pax7tm1.1Thbr,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Myf5tm1(cre)Mrc/Myf5+,Myod1tm1Jae/Myod1tm1Jae,Pax7tm1.1Thbr/Pax7tm1.1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Pax7tm1.1Thbr/Pax7tm1.1Thbr,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003852 skeletal muscle necrosis "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004069 abnormal muscle spindle morphology "anomalous structure of the sensory organs in muscle that are involved in the stretch reflex" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004232 decreased muscle weight "less than average muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1.1Sjc/Pax3tm1.2Sjc
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm2(Pdgfa)Sor/Myf5tm2(Pdgfa)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Myf5tm3(cre)Sor/Myf5tm3(cre)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004623 thoracic vertebral fusion "the union of one or more thoracic vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5tm3(cre)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1.1Sjc/Pax3tm1.2Sjc
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Myf5tm2(Pdgfa)Sor/Myf5tm2(Pdgfa)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Thbr/Myf6+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0004846 absent skeletal muscle "absence of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myf5tm1Pas/Myf5tm1Pas
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Myf5tm1Tajb/Myf5tm1Tajb,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0005247 abnormal extraocular muscle morphology "structural anomaly of any of the striated muscles that move the eye and include: superior rectus, inferrior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6tm1Tajb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Myf5tm1Tajb/Myf5tm1Tajb,Pax7tm1.1Tajb/Pax7tm1.1Tajb
Genetic Background: involves: 129S2/SvPas

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plekhm2tm1a(EUCOMM)Wtsi/Plekhm2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Lin28btm1Gqda/Lin28btm1Gqda,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Lin28btm1Gqda/Lin28btm1Gqda,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0006320 abnormal interscapular fat pad "any structural anomaly of the encapsulated adipose tissue located between the scapulae" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj,Nus1tm1.1Qrm/Nus1tm1.1Qrm
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006432 abnormal costal cartilage morphology "any structural anomaly of the nonvascular, resilient, flexible connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the costal cartilage above" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(ACTB-Edn1)1416Clou/0,E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Tg(ACTB-Edn1)1398Clou/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Tg(ACTB-Edn1)1408Clou/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Tg(ACTB-Edn1)1416Clou/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Eno/Myf6+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0008486 decreased muscle spindle number "reduced number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Gcos/Abl1+,Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6tm1Tajb,Myod1tm2.1(icre)Glh/Myod1+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj,Nus1tm1.1Qrm/Nus1tm1.1Qrm
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009136 decreased brown fat cell size "reduction in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
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Allelic Composition: SdhbGt(AP0532)Wtsi/Sdhb+,SdhcGt(BA0521)Wtsi/Sdhc+,Sdhdtm1Jlob/Sdhd+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009137 decreased brown fat lipid droplet number "reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: SdhbGt(AP0532)Wtsi/Sdhb+,SdhcGt(BA0521)Wtsi/Sdhc+,Sdhdtm1Jlob/Sdhd+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009294 increased interscapular fat pad weight 
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009295 decreased interscapular fat pad weight 
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Allelic Composition: SdhbGt(AP0532)Wtsi/Sdhb+,SdhcGt(BA0521)Wtsi/Sdhc+,Sdhdtm1Jlob/Sdhd+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl9tm1.1Agt/Bcl9tm1.1Agt,Bcl9ltm1.1Agt/Bcl9ltm1.1Agt,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0009401 increased skeletal muscle fiber diameter "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Dmdmdx-4Cv/Dmdmdx-4Cv,Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129S2/SvPas * C3H/HeHa * C57BL * M. m. castaneus * M. m musculus

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lgals1tm1Rob/Lgals1tm1Rob,Myf5tm2Pas/Myf5+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas

Allelic Composition: Pax7tm1.1Thbr/Pax7tm1.1Thbr,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Pax7tm1.1Thbr/Pax7tm1.1Thbr,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0009410 abnormal skeletal muscle satellite cell proliferation "anomaly in the ability of unfused cells in skeltal muscle to undergo expansion by cell division, usually triggered by injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129S2/SvPas

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx-4Cv/Dmdmdx-4Cv,Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129S2/SvPas * C3H/HeHa * C57BL * M. m. castaneus * M. m musculus

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Myf5tm1Pas/Myf5tm1Pas
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Myf5tm1Tajb/Myf5tm1Tajb,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf5tm1(Pdgfa)Sor/Myf5tm1(Pdgfa)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Myf5tm2(Pdgfa)Sor/Myf5tm2(Pdgfa)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1.1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myf5tm2Pas/Myf5tm2Pas
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Thbr/Myf6+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Eno/Myf6+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0011170 abnormal brown fat cell differentiation "abnormal or arrest of differentiation of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals" [CL:0000449, MGI:csmith]
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Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0011629 decreased mitochondria number "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011699 abnormal brown adipose tissue thermogenesis "any anomaly in the process of heat production in brown adipocytes" [MGI:smb]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012249 absent myotome "absence of the mesoderm that is derived from the somite that is fated to become the musculature" [MGI:anna]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Myf5tm1Pas/Myf5tm1Pas
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Myf5tm1Tajb/Myf5tm1Tajb
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0013239 impaired skeletal muscle regeneration "reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Pax7tm1.1Thbr/Pax7tm1.1Thbr,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Myf5tm2(Pdgfa)Sor/Myf5tm2(Pdgfa)Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0020520 whitened brown adipose tissue morphology "brown adipose tissue displays a morphology more closely resembling white adipose tissue (eg. unilocular lipid droplets, decreased lipid droplet numbers)" [MGI:mperry, PMID:24703692]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Sik1tm1.1Berd/Sik1tm1.1Berd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0030171 absent extraocular muscles "missing the striated muscles that are located within the orbit but are extrinsic and separate from the eyeball itself and control the movements of the eyeball and the superior eyelid" [MGI:anna]
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Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0030300 upper jaw to lower jaw transformation "homeotic transformation of upper jaw (maxillary) elements into lower jaw-like (mandibular) structures" [MGI:anna, PMID:25725491]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Tg(ACTB-Edn1)1416Clou/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020167 Tcf3 / P15806 / Transcription factor E2-alpha / P15923* / transcription factor 3*  / complex
 ENSMUSG00000030557 Mef2a / Q60929 / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA. / Q02078* / myocyte enhancer factor 2A*  / reaction / complex
 ENSMUSG00000005583 Mef2c / Q8CFN5 / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA. / Q06413* / myocyte enhancer factor 2C*  / reaction / complex






 

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