ENSG00000111049


Homo sapiens

Features
Gene ID: ENSG00000111049
  
Biological name :MYF5
  
Synonyms : MYF5 / myogenic factor 5 / P13349
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q21.31
Gene start: 80716912
Gene end: 80719673
  
Corresponding Affymetrix probe sets: 207424_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000228644
NCBI entrez gene - 4617     See in Manteia.
OMIM - 159990
RefSeq - NM_005593
RefSeq Peptide - NP_005584
swissprot - P13349
Ensembl - ENSG00000111049
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myf5ENSDARG00000007277Danio rerio
 MYF5ENSGALG00000028091Gallus gallus
 Myf5ENSMUSG00000000435Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYOD1 / P15172 / myogenic differentiation 1ENSG0000012915250
MYOG / P15173 / myogeninENSG0000012218035
MYF6 / P23409 / myogenic factor 6ENSG0000011104635


Protein motifs (from Interpro)
Interpro ID Name
 IPR002546  Myogenic basic muscle-specific protein
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR022032  Myogenic determination factor 5
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001502 cartilage condensation IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001952 regulation of cell-matrix adhesion IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development TAS
 biological_processGO:0007519 skeletal muscle tissue development TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0042693 muscle cell fate commitment ISS
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048644 muscle organ morphogenesis IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0048743 positive regulation of skeletal muscle fiber development IBA
 biological_processGO:0051149 positive regulation of muscle cell differentiation TAS
 biological_processGO:0060415 muscle tissue morphogenesis IEA
 biological_processGO:1901741 positive regulation of myoblast fusion IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISS
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding ISS


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000071564 TCF3 / P15923 / transcription factor 3  / complex / reaction
 ENSG00000081189 MEF2C / Q06413 / myocyte enhancer factor 2C  / complex / reaction
 ENSG00000068305 MEF2A / Q02078 / myocyte enhancer factor 2A  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr