ENSDARG00000007277


Danio rerio

Features
Gene ID: ENSDARG00000007277
  
Biological name :myf5
  
Synonyms : myf5 / myogenic factor 5
  
Possible biological names infered from orthology : P13349 / P24699
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 21741228
Gene end: 21745107
  
Corresponding Affymetrix probe sets: Dr.8300.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000098724
Ensembl peptide - ENSDARP00000109289
swissprot - Q5TZ22
ZFIN ID - ZDB-GENE-000616-6
Ensembl - ENSDARG00000007277
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MYF5ENSGALG00000028091Gallus gallus
 MYF5ENSG00000111049Homo sapiens
 Myf5ENSMUSG00000000435Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
myod1 / Q90477 / myogenic differentiation 1 / P10085* / P15172* / Myoblast determination protein 1 *ENSDARG0000003011046
myog / myogenin / P12979* / P15173*ENSDARG0000000943834
myf6 / Q6VNZ9 / myogenic factor 6 / P15375* / P23409*ENSDARG0000002983032


Protein motifs (from Interpro)
Interpro ID Name
 IPR002546  Myogenic basic muscle-specific protein
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR022032  Myogenic determination factor 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002074 extraocular skeletal muscle development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007498 mesoderm development IMP
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0035914 skeletal muscle cell differentiation IBA
 biological_processGO:0043282 pharyngeal muscle development IMP
 biological_processGO:0045663 positive regulation of myoblast differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048741 skeletal muscle fiber development IGI
 biological_processGO:0048743 positive regulation of skeletal muscle fiber development IBA
 biological_processGO:0055002 striated muscle cell development IGI
 biological_processGO:1901741 positive regulation of myoblast fusion IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IBA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000071 shield shield increased width , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton absent , abnormal
Show

 ZFA:0000328 cephalic musculature cephalic musculature decreased amount , abnormal
Show

 ZFA:0000414 presumptive cephalic mesoderm presumptive cephalic mesoderm gene expression disrupted , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head lacks parts or has fewer parts of type cephalic musculature , abnormal
Show

 ZFA:0001120 neuroectoderm neuroectoderm neural crest cell decreased amount , abnormal
Show

 ZFA:0001194 cranial neural crest cranial neural crest decreased amount , abnormal
cranial neural crest chondroblast decreased amount , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage malformed , abnormal
Show

 ZFA:0001220 copula copula absent , abnormal
Show

 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage malformed , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage malformed , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage absent , abnormal
Show

 ZFA:0001522 hypobranchial cartilage hypobranchial cartilage absent , abnormal
Show

 ZFA:0001606 pharyngeal arch 3 pharyngeal arch 3 has fewer parts of type chondroblast , abnormal
pharyngeal arch 3 has fewer parts of type cranial neural crest , abnormal
Show

 ZFA:0001607 pharyngeal arch 4 pharyngeal arch 4 has fewer parts of type cranial neural crest , abnormal
Show

 ZFA:0001608 pharyngeal arch 5 pharyngeal arch 5 absent , abnormal
pharyngeal arch 5 has fewer parts of type cranial neural crest , abnormal
Show

 ZFA:0001609 pharyngeal arch 6 pharyngeal arch 6 absent , abnormal
pharyngeal arch 6 has fewer parts of type cranial neural crest , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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