ENSG00000122180


Homo sapiens

Features
Gene ID: ENSG00000122180
  
Biological name :MYOG
  
Synonyms : MYOG / myogenin / P15173
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.1
Gene start: 203083132
Gene end: 203086036
  
Corresponding Affymetrix probe sets: 207282_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000241651
NCBI entrez gene - 4656     See in Manteia.
OMIM - 159980
RefSeq - NM_002479
RefSeq Peptide - NP_002470
swissprot - P15173
Ensembl - ENSG00000122180
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myogENSDARG00000009438Danio rerio
 MYOGENSGALG00000000172Gallus gallus
 MyogENSMUSG00000026459Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYF6 / P23409 / myogenic factor 6ENSG0000011104645
MYF5 / P13349 / myogenic factor 5ENSG0000011104940
MYOD1 / P15172 / myogenic differentiation 1ENSG0000012915238


Protein motifs (from Interpro)
Interpro ID Name
 IPR002546  Myogenic basic muscle-specific protein
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009629 response to gravity IEA
 biological_processGO:0010831 positive regulation of myotube differentiation IEA
 biological_processGO:0014732 skeletal muscle atrophy IEA
 biological_processGO:0014737 positive regulation of muscle atrophy IEA
 biological_processGO:0014842 regulation of skeletal muscle satellite cell proliferation IEA
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0014873 response to muscle activity involved in regulation of muscle adaptation IEA
 biological_processGO:0014878 response to electrical stimulus involved in regulation of muscle adaptation IEA
 biological_processGO:0014891 striated muscle atrophy IEA
 biological_processGO:0014894 response to denervation involved in regulation of muscle adaptation IEA
 biological_processGO:0014902 myotube differentiation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IBA
 biological_processGO:0042693 muscle cell fate commitment ISS
 biological_processGO:0042789 mRNA transcription by RNA polymerase II TAS
 biological_processGO:0043403 skeletal muscle tissue regeneration IEA
 biological_processGO:0045445 myoblast differentiation IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0045820 negative regulation of glycolytic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048741 skeletal muscle fiber development IEA
 biological_processGO:0048743 positive regulation of skeletal muscle fiber development IEA
 biological_processGO:0051149 positive regulation of muscle cell differentiation TAS
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0071259 cellular response to magnetism IEA
 biological_processGO:0071285 cellular response to lithium ion IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:1901739 regulation of myoblast fusion IEA
 biological_processGO:1901741 positive regulation of myoblast fusion IBA
 biological_processGO:1903862 positive regulation of oxidative phosphorylation IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex ISS
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISS
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000071564 TCF3 / P15923 / transcription factor 3  / complex / reaction
 ENSG00000081189 MEF2C / Q06413 / myocyte enhancer factor 2C  / complex / reaction
 ENSG00000068305 MEF2A / Q02078 / myocyte enhancer factor 2A  / reaction / complex






 

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