ENSMUSG00000026459


Mus musculus

Features
Gene ID: ENSMUSG00000026459
  
Biological name :Myog
  
Synonyms : Myog / Myogenin / P12979
  
Possible biological names infered from orthology : P15173
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 134289989
Gene end: 134292548
  
Corresponding Affymetrix probe sets: 10349993 (MoGene1.0st)   1419391_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027730
NCBI entrez gene - 17928     See in Manteia.
MGI - MGI:97276
RefSeq - NM_031189
RefSeq Peptide - NP_112466
swissprot - P12979
Ensembl - ENSMUSG00000026459
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myogENSDARG00000009438Danio rerio
 MYOGENSGALG00000000172Gallus gallus
 MYOGENSG00000122180Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myf6 / P15375 / Myogenic factor 6 / P23409*ENSMUSG0000003592345
Myf5 / P24699 / Myogenic factor 5 / P13349*ENSMUSG0000000043538
Myod1 / P10085 / Myoblast determination protein 1 / P15172* / myogenic differentiation 1*ENSMUSG0000000947134


Protein motifs (from Interpro)
Interpro ID Name
 IPR002546  Myogenic basic muscle-specific protein
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IGI
 biological_processGO:0007519 skeletal muscle tissue development TAS
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010831 positive regulation of myotube differentiation IDA
 biological_processGO:0014737 positive regulation of muscle atrophy IMP
 biological_processGO:0014842 regulation of skeletal muscle satellite cell proliferation IMP
 biological_processGO:0014873 response to muscle activity involved in regulation of muscle adaptation ISS
 biological_processGO:0014878 response to electrical stimulus involved in regulation of muscle adaptation ISS
 biological_processGO:0014891 striated muscle atrophy IMP
 biological_processGO:0014894 response to denervation involved in regulation of muscle adaptation IDA
 biological_processGO:0014902 myotube differentiation IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IBA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IC
 biological_processGO:0045663 positive regulation of myoblast differentiation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0048743 positive regulation of skeletal muscle fiber development IMP
 biological_processGO:0071158 positive regulation of cell cycle arrest IDA
 biological_processGO:0071285 cellular response to lithium ion IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071392 cellular response to estradiol stimulus IDA
 biological_processGO:1901739 regulation of myoblast fusion IMP
 biological_processGO:1901741 positive regulation of myoblast fusion IBA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0032993 protein-DNA complex ISS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
Show

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Myogtm1Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Myogtm1Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myog+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myogtm1Yin/Myogtm1Yin
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Myogtm1Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myogtm3Whk/Myogtm3Whk,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: B6.129-Elntm1Dyl

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: B6.129-Elntm1Dyl

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Myogtm1Yin/Myogtm1Yin
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Myogtm1Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nox3het-2J/Nox3het-2J
Genetic Background: B10.Q-H2q/SgJ

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1+,Myogtm1Whk/Myog+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002263 abnormal laryngeal muscle morphology "any structural anomaly of the muscles associated with the larynx " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009408 decreased skeletal muscle fiber density "decrease in the number of skeletal muscle fibers in a given cross-sectional area of a skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Myogtm3Whk/Myogtm3Whk,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myogtm1Yin/Myogtm1Yin
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Myogtm1Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0012280 abnormal sternebra size "atypical size of any of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005583 Mef2c / Q8CFN5 / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA. / Q06413* / myocyte enhancer factor 2C*  / reaction / complex
 ENSMUSG00000030557 Mef2a / Q60929 / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA. / Q02078* / myocyte enhancer factor 2A*  / complex / reaction
 ENSMUSG00000020167 Tcf3 / P15806 / Transcription factor E2-alpha / P15923* / transcription factor 3*  / complex






 

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