ENSMUSG00000035923


Mus musculus

Features
Gene ID: ENSMUSG00000035923
  
Biological name :Myf6
  
Synonyms : Myf6 / Myogenic factor 6 / P15375
  
Possible biological names infered from orthology : P23409
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D1
Gene start: 107492853
Gene end: 107494737
  
Corresponding Affymetrix probe sets: 10372230 (MoGene1.0st)   1419150_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047529
NCBI entrez gene - 17878     See in Manteia.
MGI - MGI:97253
RefSeq - NM_008657
RefSeq Peptide - NP_032683
swissprot - P15375
swissprot - Q0VEJ7
Ensembl - ENSMUSG00000035923
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myf6ENSDARG00000029830Danio rerio
 MYF6ENSGALG00000010936Gallus gallus
 MYF6ENSG00000111046Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myog / P12979 / Myogenin / P15173*ENSMUSG0000002645942
Myod1 / P10085 / Myoblast determination protein 1 / P15172* / myogenic differentiation 1*ENSMUSG0000000947139
Myf5 / P24699 / Myogenic factor 5 / P13349*ENSMUSG0000000043538


Protein motifs (from Interpro)
Interpro ID Name
 IPR002546  Myogenic basic muscle-specific protein
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007519 skeletal muscle tissue development TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0043403 skeletal muscle tissue regeneration IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048743 positive regulation of skeletal muscle fiber development IBA
 biological_processGO:0060415 muscle tissue morphogenesis IMP
 biological_processGO:1901741 positive regulation of myoblast fusion IBA
 cellular_componentGO:0005634 nucleus TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding TAS
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
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Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf6tm1Thbr/Myf6tm1Thbr
Genetic Background: either: (involves: 129S4/SvJae-Myf6tm1Thbr) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Eno/Myf6+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1+,Myogtm1Whk/Myog+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf6tm1(cre)Mrc/Myf6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Abl1tm1Gcos/Abl1+,Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6tm1Tajb,Myod1tm2.1(icre)Glh/Myod1+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000737 abnormal myotome development "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]
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Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Eno/Myf6+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf6tm1(cre)Mrc/Myf6tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf6tm1(cre)Mrc/Myf6tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf6tm1(cre)Mrc/Myf6tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myf6tm1Thbr/Myf6tm1Thbr
Genetic Background: either: (involves: 129S4/SvJae-Myf6tm1Thbr) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Pou4f2tm3Whk/Pou4f2tm3Whk,Pou4f3tm1Whk/Pou4f3tm1Whk
Genetic Background: Not Specified

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0002036 rhabdomyosarcoma "malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw,Cpn1tm1Raw/Cpn1tm1Raw
Genetic Background: B6.129-C3ar1tm1Raw Cpn1tm1Raw

Allelic Composition: Myf6tm1(cre)Mrc/Myf6+,Pax3tm1Mrc/Pax3tm1Mrc,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Myf6tm1(cre)Mrc/Myf6+,Pax3tm1Mrc/Pax3tm1Mrc,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Myf6tm1(cre)Mrc/Myf6+,Pax3tm1Mrc/Pax3tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sortm1(DTA)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1+,Myogtm1Whk/Myog+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002280 abnormal intercostal muscle morphology "anomaly in the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf6tm1(cre)Mrc/Myf6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003818 abnormal eye muscle development "malformation or arrest of differentiation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6tm1Tajb
Genetic Background: involves: 129S2/SvPas

 MP:0003939 abnormal myotome morphology "structural anomaly in the mesoderm that is derived from the somite that is fated to beome the musculature" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf6tm1Thbr/Myf6tm1Thbr
Genetic Background: either: (involves: 129S4/SvJae-Myf6tm1Thbr) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Thbr/Myf6+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0004677 truncated ribs "ribs that terminate abruptly as if having an end or point cut off" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004846 absent skeletal muscle "absence of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0005247 abnormal extraocular muscle morphology "structural anomaly of any of the striated muscles that move the eye and include: superior rectus, inferrior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myf5tm1Jae/Myf5tm1Jae
Genetic Background: either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6tm1Tajb
Genetic Background: involves: 129S2/SvPas

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Thbr/Myf6tm1Thbr
Genetic Background: either: (involves: 129S4/SvJae-Myf6tm1Thbr) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Eno/Myf6+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Thbr/Myf6tm1Thbr
Genetic Background: either: (involves: 129S4/SvJae-Myf6tm1Thbr) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Gcos/Abl1+,Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6tm1Tajb,Myod1tm2.1(icre)Glh/Myod1+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf6tm1(cre)Mrc/Myf6tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf6tm1(cre)Mrc/Myf6tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Myf6tm1Thbr/Myf6tm1Thbr
Genetic Background: either: (involves: 129S4/SvJae-Myf6tm1Thbr) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf6tm1(cre)Mrc/Myf6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Thbr/Myf6+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Wb/Myf6+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Eno/Myf6+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030557 Mef2a / Q60929 / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA. / Q02078* / myocyte enhancer factor 2A*  / complex / reaction
 ENSMUSG00000005583 Mef2c / Q8CFN5 / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA. / Q06413* / myocyte enhancer factor 2C*  / complex / reaction
 ENSMUSG00000020167 Tcf3 / P15806 / Transcription factor E2-alpha / P15923* / transcription factor 3*  / complex






 

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