ENSMUSG00000053477


Mus musculus

Features
Gene ID: ENSMUSG00000053477
  
Biological name :Tcf4
  
Synonyms : Q60722 / Tcf4 / transcription factor 4
  
Possible biological names infered from orthology : P15884
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E2
Gene start: 69343356
Gene end: 69689079
  
Corresponding Affymetrix probe sets: 10456522 (MoGene1.0st)   1416723_at (Mouse Genome 430 2.0 Array)   1416724_x_at (Mouse Genome 430 2.0 Array)   1416725_at (Mouse Genome 430 2.0 Array)   1424089_a_at (Mouse Genome 430 2.0 Array)   1434148_at (Mouse Genome 430 2.0 Array)   1434149_at (Mouse Genome 430 2.0 Array)   1439336_at (Mouse Genome 430 2.0 Array)   1440015_at (Mouse Genome 430 2.0 Array)   1458201_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144045
Ensembl peptide - ENSMUSP00000143987
Ensembl peptide - ENSMUSP00000144064
Ensembl peptide - ENSMUSP00000147155
Ensembl peptide - ENSMUSP00000147136
Ensembl peptide - ENSMUSP00000146869
Ensembl peptide - ENSMUSP00000144670
Ensembl peptide - ENSMUSP00000144655
Ensembl peptide - ENSMUSP00000144649
Ensembl peptide - ENSMUSP00000144647
Ensembl peptide - ENSMUSP00000144646
Ensembl peptide - ENSMUSP00000144599
Ensembl peptide - ENSMUSP00000144583
Ensembl peptide - ENSMUSP00000144544
Ensembl peptide - ENSMUSP00000144519
Ensembl peptide - ENSMUSP00000144512
Ensembl peptide - ENSMUSP00000144494
Ensembl peptide - ENSMUSP00000144488
Ensembl peptide - ENSMUSP00000144473
Ensembl peptide - ENSMUSP00000144407
Ensembl peptide - ENSMUSP00000144397
Ensembl peptide - ENSMUSP00000144386
Ensembl peptide - ENSMUSP00000144376
Ensembl peptide - ENSMUSP00000144338
Ensembl peptide - ENSMUSP00000144332
Ensembl peptide - ENSMUSP00000144315
Ensembl peptide - ENSMUSP00000144298
Ensembl peptide - ENSMUSP00000144285
Ensembl peptide - ENSMUSP00000144273
Ensembl peptide - ENSMUSP00000144221
Ensembl peptide - ENSMUSP00000144219
Ensembl peptide - ENSMUSP00000144209
Ensembl peptide - ENSMUSP00000144169
Ensembl peptide - ENSMUSP00000144154
Ensembl peptide - ENSMUSP00000144080
Ensembl peptide - ENSMUSP00000144070
Ensembl peptide - ENSMUSP00000067318
Ensembl peptide - ENSMUSP00000077577
Ensembl peptide - ENSMUSP00000110628
Ensembl peptide - ENSMUSP00000110629
Ensembl peptide - ENSMUSP00000110631
Ensembl peptide - ENSMUSP00000110633
Ensembl peptide - ENSMUSP00000110636
Ensembl peptide - ENSMUSP00000143820
Ensembl peptide - ENSMUSP00000143857
Ensembl peptide - ENSMUSP00000143875
Ensembl peptide - ENSMUSP00000143892
Ensembl peptide - ENSMUSP00000143950
NCBI entrez gene - 21413     See in Manteia.
MGI - MGI:98506
RefSeq - XM_017317863
RefSeq - NM_001083967
RefSeq - NM_013685
RefSeq - XM_006525746
RefSeq - XM_006525747
RefSeq - XM_006525748
RefSeq - XM_006525749
RefSeq - XM_006525750
RefSeq - XM_006525751
RefSeq - XM_006525752
RefSeq - XM_006525753
RefSeq - XM_006525757
RefSeq - XM_006525759
RefSeq - XM_006525760
RefSeq - XM_006525761
RefSeq - XM_006525762
RefSeq - XM_006525763
RefSeq - XM_006525764
RefSeq - XM_006525766
RefSeq - XM_017317854
RefSeq - XM_017317855
RefSeq - XM_017317856
RefSeq - XM_017317857
RefSeq - XM_017317858
RefSeq - XM_017317859
RefSeq - XM_017317860
RefSeq - XM_017317861
RefSeq - XM_017317862
RefSeq Peptide - NP_001077436
RefSeq Peptide - NP_038713
swissprot - A0A0J9YU75
swissprot - A0A0J9YU37
swissprot - A0A0J9YTX3
swissprot - A0A0J9YTW1
swissprot - A0A0J9YTU7
swissprot - Q91YV0
swissprot - A0A0J9YTR9
swissprot - Q60722
swissprot - Q8BPX7
swissprot - Q91XK1
swissprot - E9Q8G4
swissprot - A0A1B0GXC8
swissprot - A0A140LJC0
swissprot - A0A140LJA2
swissprot - A0A140LIL4
swissprot - A0A0J9YVI1
swissprot - A0A0J9YVG8
swissprot - A0A0J9YVG2
swissprot - A0A0J9YVC6
swissprot - A0A0J9YVB3
swissprot - A0A0J9YV88
swissprot - A0A0J9YV54
swissprot - A0A0J9YV50
swissprot - A0A0J9YV39
swissprot - A0A0J9YUZ0
swissprot - A0A0J9YUY3
swissprot - A0A0J9YUX6
swissprot - A0A0J9YUW9
swissprot - A0A0J9YUT7
swissprot - A0A0J9YUT3
swissprot - A0A0J9YUS2
swissprot - A0A0J9YUR0
swissprot - A0A0J9YUP9
swissprot - A0A0J9YUK1
swissprot - A0A0J9YUG4
swissprot - A0A0J9YUF5
swissprot - A0A0J9YU91
swissprot - A0A0J9YU99
swissprot - A0A0J9YU89
Ensembl - ENSMUSG00000053477
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01086139.1ENSDARG00000113371Danio rerio
 TCF4ENSDARG00000107408Danio rerio
 ENSGALG00000033770Gallus gallus
 TCF4ENSG00000196628Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tcf12 / Q61286 / transcription factor 12 / Q99081*ENSMUSG0000003222861
Tcf3 / P15806 / Transcription factor E2-alpha / P15923* / transcription factor 3*ENSMUSG0000002016747


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006352 DNA-templated transcription, initiation IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0016525 negative regulation of angiogenesis IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042118 endothelial cell activation IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0065004 protein-DNA complex assembly IDA
 biological_processGO:1900746 regulation of vascular endothelial growth factor signaling pathway IDA
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0070369 beta-catenin-TCF7L2 complex ISO
 cellular_componentGO:1990907 beta-catenin-TCF complex ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001087 obsolete transcription factor activity, TFIIB-class binding IDA
 molecular_functionGO:0001093 TFIIB-class transcription factor binding IDA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0043425 bHLH transcription factor binding IBA
 molecular_functionGO:0043621 protein self-association IMP
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Tcf4em1Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Tcf4em2Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Tyrp1b/Tyrp1b-173G
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tyrp1b/Tyrp1b-173G
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Allelic Composition: Tcf4tm1Zhu/Tcf4tm1Zhu
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tcf4em1Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Tcf4em1Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Tcf4em1Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Tcf4em1Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf4tm1Zhu/Tcf4+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1b/Tyrp1b-173G
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptdss1tm1Jev/Ptdss1tm1Jev,Ptdss2Gt(KST314)Byg/Ptdss2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Tcf4em1Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Tcf4em2Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tcf4em1Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Tcf4em2Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptdss1tm1Jev/Ptdss1tm1Jev,Ptdss2Gt(KST314)Byg/Ptdss2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tcf4em1Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Tcf4em2Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0003234 enhanced NMDA-mediated synaptic currents "increase in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Tcf4em1Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptdss1tm1Jev/Ptdss1tm1Jev,Ptdss2Gt(KST314)Byg/Ptdss2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Tcf4tm1.1Hmb/Tcf4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tyrp1b/Tyrp1b-173G
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tcf4em1Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map7mshi/Map7mshi
Genetic Background: BALB/cBy

Allelic Composition: Tcf4tm1Zhu/Tcf4+,Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf4tm1Zhu/Tcf4+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf4em1Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Map7mshi/Map7mshi
Genetic Background: BALB/cBy

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf4tm1Zhu/Tcf4+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Tcf4tm1.1Hmb/Tcf4tm1.1Hmb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tcf4tm1Zhu/Tcf4+,Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tcf4tm1Zhu/Tcf4tm1Zhu
Genetic Background: involves: 129P2/OlaHsd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011620 abnormal habituation to a new environment "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [MGI:csmith]
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Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Tcf4tm1Hmb/Tcf4+,Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Tcf4em1Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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