ENSMUSG00000032228


Mus musculus

Features
Gene ID: ENSMUSG00000032228
  
Biological name :Tcf12
  
Synonyms : Q61286 / Tcf12 / transcription factor 12
  
Possible biological names infered from orthology : Q99081
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 71842688
Gene end: 72111871
  
Corresponding Affymetrix probe sets: 10594879 (MoGene1.0st)   1421908_a_at (Mouse Genome 430 2.0 Array)   1427670_a_at (Mouse Genome 430 2.0 Array)   1439209_at (Mouse Genome 430 2.0 Array)   1439619_at (Mouse Genome 430 2.0 Array)   1446294_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034755
Ensembl peptide - ENSMUSP00000138807
Ensembl peptide - ENSMUSP00000138832
Ensembl peptide - ENSMUSP00000138925
Ensembl peptide - ENSMUSP00000138939
Ensembl peptide - ENSMUSP00000139364
Ensembl peptide - ENSMUSP00000139365
Ensembl peptide - ENSMUSP00000138952
Ensembl peptide - ENSMUSP00000138978
Ensembl peptide - ENSMUSP00000139008
Ensembl peptide - ENSMUSP00000139084
Ensembl peptide - ENSMUSP00000139139
Ensembl peptide - ENSMUSP00000139233
Ensembl peptide - ENSMUSP00000139248
Ensembl peptide - ENSMUSP00000139268
Ensembl peptide - ENSMUSP00000139284
Ensembl peptide - ENSMUSP00000139334
NCBI entrez gene - 21406     See in Manteia.
MGI - MGI:101877
RefSeq - XM_017313270
RefSeq - NM_001253862
RefSeq - NM_001253863
RefSeq - NM_001253864
RefSeq - NM_001253865
RefSeq - NM_011544
RefSeq - XM_006510994
RefSeq - XM_006510995
RefSeq - XM_006510996
RefSeq - XM_006510997
RefSeq - XM_006510998
RefSeq - XM_006510999
RefSeq - XM_006511000
RefSeq - XM_006511002
RefSeq Peptide - NP_035674
RefSeq Peptide - NP_001240791
RefSeq Peptide - NP_001240792
RefSeq Peptide - NP_001240793
RefSeq Peptide - NP_001240794
swissprot - V9GXG5
swissprot - V9GXM8
swissprot - V9GXP0
swissprot - V9GXQ6
swissprot - V9GXR6
swissprot - Q3UXQ3
swissprot - Q61286
swissprot - V9GWS4
swissprot - V9GX18
swissprot - V9GWU2
swissprot - V9GX29
swissprot - V9GX46
swissprot - V9GX66
swissprot - V9GXC3
Ensembl - ENSMUSG00000032228
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tcf12ENSDARG00000004714Danio rerio
 TCF12ENSGALG00000004304Gallus gallus
 TCF12ENSG00000140262Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tcf4 / Q60722 / transcription factor 4 / P15884*ENSMUSG0000005347758
Tcf3 / P15806 / Transcription factor E2-alpha / P15923* / transcription factor 3*ENSMUSG0000002016746


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0035497 cAMP response element binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0043425 bHLH transcription factor binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0046332 SMAD binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

Allelic Composition: Tcf12tm1Zhu/Tcf12tm1Zhu
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf4tm1Zhu/Tcf4+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Runx1tm2Spe/Runx1tm3Spe,Tg(KRT5-cre)5132Jlj/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J)

Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL/J

Allelic Composition: Tcf12tm1Zhu/Tcf12tm1Zhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

Allelic Composition: Tcf12tm1Zhu/Tcf12tm2Zhu
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Tcf12tm1Zhu/Tcf12tm1Zhu
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL/J

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL/J

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Tcf12tm1Zhu/Tcf12tm1Zhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL/J

Allelic Composition: Tcf12tm1Zhu/Tcf12tm1Zhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL/J

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: C57BL/6 * SJL/J

Allelic Composition: Tcf12tm3Zhu/Tcf12tm3Zhu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Tcf12tm1Zhu/Tcf12tm1Zhu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map7mshi/Map7mshi
Genetic Background: BALB/cBy

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf4tm1Zhu/Tcf4+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Map7mshi/Map7mshi
Genetic Background: BALB/cBy

Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf4tm1Zhu/Tcf4+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Tcf12tm2Zhu/Tcf12tm2Zhu
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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