ENSDARG00000009418


Danio rerio

Features
Gene ID: ENSDARG00000009418
  
Biological name :mef2cb
  
Synonyms : mef2cb / myocyte enhancer factor 2cb
  
Possible biological names infered from orthology : MEF2C / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA. / myocyte enhancer factor 2C / Q06413 / Q8CFN5
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 48179340
Gene end: 48307804
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000150568
Ensembl peptide - ENSDARP00000157387
Ensembl peptide - ENSDARP00000154164
Ensembl peptide - ENSDARP00000044082
Ensembl peptide - ENSDARP00000114315
Ensembl peptide - ENSDARP00000138296
Ensembl peptide - ENSDARP00000145338
Ensembl peptide - ENSDARP00000149412
NCBI entrez gene - 798771     See in Manteia.
RefSeq - NM_001130962
RefSeq Peptide - NP_001124434
swissprot - A2BGA7
swissprot - A0A0R4ITE5
swissprot - F1QNL1
ZFIN ID - ZDB-GENE-040901-7
Ensembl - ENSDARG00000009418
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MEF2CENSGALG00000014645Gallus gallus
 MEF2CENSG00000081189Homo sapiens
 Mef2cENSMUSG00000005583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mef2ca / myocyte enhancer factor 2caENSDARG0000002976472
mef2aa / myocyte enhancer factor 2aa / MEF2A* / Q60929* / Q02078* / myocyte enhancer factor 2A* / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA.*ENSDARG0000003175654
mef2d / myocyte enhancer factor 2d / Q14814* / Q63943* / Myocyte-specific enhancer factor 2D *ENSDARG0000004023749
mef2ab / myocyte enhancer factor 2abENSDARG0000005752733
mef2b / myocyte enhancer factor 2b / Q02080* / BORCS8-MEF2B* / BORCS8-MEF2B readthrough*ENSDARG0000009317031


Protein motifs (from Interpro)
Interpro ID Name
 IPR002100  Transcription factor, MADS-box
 IPR022102  Holliday junction regulator protein family C-terminal
 IPR033896  MADS MEF2-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IGI
 biological_processGO:0055013 cardiac muscle cell development IGI
 biological_processGO:0060914 heart formation IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
Show

 ZFA:0000114 heart heart malformed , abnormal
heart edematous , abnormal
heart linear , abnormal
Show

 ZFA:0000173 bulbus arteriosus bulbus arteriosus decreased size , abnormal
bulbus arteriosus aplastic , abnormal
Show

 ZFA:0000360 heart tube heart tube shortened , abnormal
Show

 ZFA:0000471 atrium atrium physical object quality , abnormal
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal aplastic , abnormal
Show

 ZFA:0001718 presumptive atrium heart tube presumptive atrium heart tube decreased volume , abnormal
Show

 ZFA:0001719 presumptive cardiac ventricle heart tube presumptive cardiac ventricle heart tube decreased volume , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000042021 O42376 / mapk12a / mitogen-activated protein kinase 12a / O08911* / MAPK12* / P53778* / mitogen-activated protein kinase 12*  / complex / reaction
 ENSDARG00000029830 myf6 / Q6VNZ9 / myogenic factor 6 / P15375* / P23409*  / complex / reaction
 ENSDARG00000045836 mapk11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / reaction / complex
 ENSDARG00000006409 mapk12b / mitogen-activated protein kinase 12b / P53778* / MAPK12* / O08911* / mitogen-activated protein kinase 12*  / reaction / complex
 ENSDARG00000028721 mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*  / reaction / complex
 ENSDARG00000000857 Q9DGE2 / mapk14a / mitogen-activated protein kinase 14a / P47811* / Q16539* / MAPK14* / mitogen-activated protein kinase 14*  / complex / reaction
 ENSDARG00000030110 myod1 / Q90477 / myogenic differentiation 1 / P10085* / P15172* / Myoblast determination protein 1 *  / reaction / complex






 

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