ENSDARG00000031756


Danio rerio

Features
Gene ID: ENSDARG00000031756
  
Biological name :mef2aa
  
Synonyms : mef2aa / myocyte enhancer factor 2aa
  
Possible biological names infered from orthology : MEF2A / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA. / myocyte enhancer factor 2A / Q02078 / Q60929
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 23187419
Gene end: 23356077
  
Corresponding Affymetrix probe sets: Dr.266.1.S1_at (Zebrafish Array)   NM_131301_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000156891
Ensembl peptide - ENSDARP00000157383
Ensembl peptide - ENSDARP00000021792
Ensembl peptide - ENSDARP00000110624
Ensembl peptide - ENSDARP00000116960
Ensembl peptide - ENSDARP00000123273
Ensembl peptide - ENSDARP00000139238
Ensembl peptide - ENSDARP00000154945
NCBI entrez gene - 30564     See in Manteia.
RefSeq - NM_131301
RefSeq Peptide - NP_571376
swissprot - Q1LXH4
swissprot - Q1LXH5
swissprot - Q1LXH6
swissprot - A0A0R4IRM3
swissprot - Q1LXH3
ZFIN ID - ZDB-GENE-990415-163
Ensembl - ENSDARG00000031756
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MEF2AENSGALG00000032366Gallus gallus
 MEF2AENSG00000068305Homo sapiens
 Mef2aENSMUSG00000030557Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mef2ca / myocyte enhancer factor 2caENSDARG0000002976457
mef2cb / myocyte enhancer factor 2cb / MEF2C* / Q8CFN5* / Q06413* / myocyte enhancer factor 2C* / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA.*ENSDARG0000000941857
mef2d / myocyte enhancer factor 2d / Q14814* / Q63943* / Myocyte-specific enhancer factor 2D *ENSDARG0000004023755
mef2ab / myocyte enhancer factor 2abENSDARG0000005752737
mef2b / myocyte enhancer factor 2b / Q02080* / BORCS8-MEF2B* / BORCS8-MEF2B readthrough*ENSDARG0000009317032


Protein motifs (from Interpro)
Interpro ID Name
 IPR002100  Transcription factor, MADS-box
 IPR022102  Holliday junction regulator protein family C-terminal
 IPR033896  MADS MEF2-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle dilated , abnormal
cardiac ventricle decreased functionality , abnormal
Show

 ZFA:0000054 pericardium pericardium structure , ameliorated
pericardium edematous , abnormal
Show

 ZFA:0000114 heart heart contractility , abnormal
heart functionality , ameliorated
heart decreased functionality , abnormal
Show

 ZFA:0000155 somite somite U-shaped , abnormal
Show

 ZFA:0000471 atrium atrium dilated , abnormal
Show

 ZFA:0000671 horizontal myoseptum horizontal myoseptum aplastic , abnormal
Show

 ZFA:0001086 muscle pioneer muscle pioneer decreased amount , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
post-vent region somite apoptotic , abnormal
Show

 ZFA:0001462 somite border somite border posterior region surface feature shape , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell myofibril disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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