ENSDARG00000029764


Danio rerio

Features
Gene ID: ENSDARG00000029764
  
Biological name :mef2ca
  
Synonyms : mef2ca / myocyte enhancer factor 2ca
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 43544814
Gene end: 43655449
  
Corresponding Affymetrix probe sets: Dr.267.1.S1_at (Zebrafish Array)   Dr.3182.1.A1_at (Zebrafish Array)   NM_131312_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000119434
Ensembl peptide - ENSDARP00000122497
Ensembl peptide - ENSDARP00000088204
Ensembl peptide - ENSDARP00000089908
Ensembl peptide - ENSDARP00000113573
Ensembl peptide - ENSDARP00000116118
Ensembl peptide - ENSDARP00000118804
NCBI entrez gene - 30575     See in Manteia.
RefSeq - NM_131312
RefSeq - XM_005169228
RefSeq Peptide - NP_571387
swissprot - F1RAB7
swissprot - Q6PCS3
swissprot - E9QCL1
swissprot - F1Q9U5
swissprot - F1QRV7
ZFIN ID - ZDB-GENE-980526-253
Ensembl - ENSDARG00000029764
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mef2cb / myocyte enhancer factor 2cb / MEF2C* / Q8CFN5* / Q06413* / myocyte enhancer factor 2C* / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA.*ENSDARG0000000941875
mef2aa / myocyte enhancer factor 2aa / MEF2A* / Q60929* / Q02078* / myocyte enhancer factor 2A* / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA.*ENSDARG0000003175656
mef2d / myocyte enhancer factor 2d / Q14814* / Q63943* / Myocyte-specific enhancer factor 2D *ENSDARG0000004023751
mef2ab / myocyte enhancer factor 2abENSDARG0000005752735
mef2b / myocyte enhancer factor 2b / Q02080* / BORCS8-MEF2B* / BORCS8-MEF2B readthrough*ENSDARG0000009317032


Protein motifs (from Interpro)
Interpro ID Name
 IPR002100  Transcription factor, MADS-box
 IPR022102  Holliday junction regulator protein family C-terminal
 IPR033896  MADS MEF2-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0030241 skeletal muscle myosin thick filament assembly IGI
 biological_processGO:0036076 ligamentous ossification IMP
 biological_processGO:0045667 regulation of osteoblast differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0055013 cardiac muscle cell development IGI
 biological_processGO:0060349 bone morphogenesis IMP
 biological_processGO:0060536 cartilage morphogenesis IMP
 biological_processGO:0060914 heart formation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton morphology , abnormal
Show

 ZFA:0000114 heart heart aplastic , abnormal
heart hypoplastic , abnormal
heart immature , abnormal
Show

 ZFA:0000250 opercle opercle fused with branchiostegal ray 3 , abnormal
opercle increased variability , abnormal
opercle size , abnormal
opercle increased size , abnormal
opercle distended , abnormal
opercle osteoprogenitor cell decreased amount , abnormal
Show

 ZFA:0000360 heart tube heart tube aplastic , abnormal
heart tube decreased thickness , abnormal
heart tube hypoplastic , abnormal
heart tube shape , abnormal
Show

 ZFA:0000476 branchiostegal ray branchiostegal ray malformed , abnormal
branchiostegal ray fan-shaped , abnormal
branchiostegal ray increased size , abnormal
branchiostegal ray fused with opercle , abnormal
Show

 ZFA:0000547 mouth mouth concave 3-D shape , abnormal
Show

 ZFA:0000737 cranium cranium has extra parts of type cranial cartilage , abnormal
cranium bone tissue mislocalised , abnormal
Show

 ZFA:0001056 myotome myotome decreased volume , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
Show

 ZFA:0001114 head head has extra parts of type bone tissue , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
Meckels cartilage mislocalised posteriorly , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch quality , abnormal
ventral mandibular arch decreased size , abnormal
Show

 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton quality , abnormal
Show

 ZFA:0001280 branchiostegal ray 3 branchiostegal ray 3 increased variability , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased size , abnormal
ceratohyal cartilage split , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage deformed , abnormal
Show

 ZFA:0001510 basihyal cartilage basihyal cartilage shape , abnormal
basihyal cartilage hyperplastic , abnormal
Show

 ZFA:0001628 replacement bone replacement bone osteoblast mislocalised , abnormal
Show

 ZFA:0001632 portion of connective tissue portion of connective tissue decreased amount , abnormal
Show

 ZFA:0005465 ceratohyal-branchiostegal ray joint ceratohyal-branchiostegal ray joint morphology , abnormal
Show

 ZFA:0005885 operculohyoid ligament operculohyoid ligament osteoblast mislocalised , abnormal
operculohyoid ligament ossified , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell disorganized , abnormal
Show

 ZFA:0009115 skeletal muscle cell skeletal muscle cell myofibril decreased diameter , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell undifferentiated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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