ENSGALG00000032366


Gallus gallus

Features
Gene ID: ENSGALG00000032366
  
Biological name :MEF2A
  
Synonyms : MEF2A / myocyte enhancer factor 2A
  
Possible biological names infered from orthology : Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA. / Q02078 / Q60929
  
Species: Gallus gallus
  
Chr. number: 10
Strand: 1
Band:
Gene start: 17014586
Gene end: 17092303
  
Corresponding Affymetrix probe sets: Gga.10350.1.S1_at (Chicken Array)   Gga.10350.1.S1_s_at (Chicken Array)   Gga.1908.1.S1_at (Chicken Array)   Gga.1908.1.S2_at (Chicken Array)   Gga.5064.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050266
NCBI entrez gene - 395670     See in Manteia.
RefSeq - XM_015292081
RefSeq - NM_204864
RefSeq - XM_015292079
RefSeq - XM_015292080
RefSeq - XM_015292072
RefSeq - XM_015292073
RefSeq - XM_015292074
RefSeq - XM_015292075
RefSeq - XM_015292076
RefSeq - XM_015292077
RefSeq - XM_015292078
RefSeq Peptide - NP_990195
swissprot - A0A1D5PBY4
Ensembl - ENSGALG00000032366
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mef2aaENSDARG00000031756Danio rerio
 MEF2AENSG00000068305Homo sapiens
 Mef2aENSMUSG00000030557Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MEF2D / myocyte enhancer factor 2D / Q14814* / Q63943* / Myocyte-specific enhancer factor 2D *ENSGALG0000003778762
MEF2C / myocyte enhancer factor 2C / Q06413* / Q8CFN5* / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA.*ENSGALG0000001464559
MEF2B* / Q02080* / BORCS8-MEF2B* / BORCS8-MEF2B readthrough* / myocyte enhancer factor 2B*ENSGALG0000003755822


Protein motifs (from Interpro)
Interpro ID Name
 IPR002100  Transcription factor, MADS-box
 IPR022102  Holliday junction regulator protein family C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000002 mitochondrial genome maintenance IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048311 mitochondrion distribution IEA
 biological_processGO:0055005 ventricular cardiac myofibril assembly IEA
 biological_processGO:0061337 cardiac conduction IEA
 biological_processGO:0070375 ERK5 cascade IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001093 TCF3 / transcription factor 3 / P15806* / P15923* / Transcription factor E2-alpha *  / reaction / complex
 ENSGALG00000010936 MYF6 / myogenic factor 6 / P15375* / P23409*  / reaction / complex
 ENSGALG00000000172 MYOG / P17920 / Myogenin / P12979* / P15173*  / reaction / complex
 ENSGALG00000040023 MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / reaction / complex
 ENSGALG00000019384 MAPK12 / mitogen-activated protein kinase 12 / O08911* / P53778*  / reaction / complex
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / reaction / complex






 

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