ENSGALG00000014645


Gallus gallus

Features
Gene ID: ENSGALG00000014645
  
Biological name :MEF2C
  
Synonyms : MEF2C / myocyte enhancer factor 2C
  
Possible biological names infered from orthology : Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA. / Q06413 / Q8CFN5
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 60313313
Gene end: 60436293
  
Corresponding Affymetrix probe sets: Gga.5323.1.S1_at (Chicken Array)   Gga.5323.1.S1_s_at (Chicken Array)   GgaAffx.25261.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000023559
Ensembl peptide - ENSGALP00000054416
Ensembl peptide - ENSGALP00000051990
Ensembl peptide - ENSGALP00000047600
NCBI entrez gene - 769007     See in Manteia.
RefSeq - XM_015280567
RefSeq - XM_015280563
RefSeq - XM_015280564
RefSeq - XM_015280565
RefSeq - XM_015280566
RefSeq - XM_004949410
RefSeq - XM_015280557
RefSeq - XM_015280558
RefSeq - XM_015280559
RefSeq - XM_015280560
RefSeq - XM_015280562
swissprot - E1C5C0
swissprot - A0A1D5PNH4
swissprot - A0A1D5PGR7
swissprot - A0A1D5P4J1
Ensembl - ENSGALG00000014645
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mef2cbENSDARG00000009418Danio rerio
 MEF2CENSG00000081189Homo sapiens
 Mef2cENSMUSG00000005583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MEF2A / myocyte enhancer factor 2A / Q02078* / Q60929* / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA.*ENSGALG0000003236661
MEF2D / myocyte enhancer factor 2D / Q14814* / Q63943* / Myocyte-specific enhancer factor 2D *ENSGALG0000003778755
MEF2B* / Q02080* / BORCS8-MEF2B* / BORCS8-MEF2B readthrough* / myocyte enhancer factor 2B*ENSGALG0000003755824


Protein motifs (from Interpro)
Interpro ID Name
 IPR002100  Transcription factor, MADS-box
 IPR022102  Holliday junction regulator protein family C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001782 B cell homeostasis IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0002467 germinal center formation IEA
 biological_processGO:0002634 regulation of germinal center formation IEA
 biological_processGO:0003138 primary heart field specification IEA
 biological_processGO:0003139 secondary heart field specification IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003185 sinoatrial valve morphogenesis IEA
 biological_processGO:0003211 cardiac ventricle formation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006959 humoral immune response IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0007521 muscle cell fate determination IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010694 positive regulation of alkaline phosphatase activity IEA
 biological_processGO:0014033 neural crest cell differentiation IEA
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IEA
 biological_processGO:0014902 myotube differentiation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030220 platelet formation IEA
 biological_processGO:0030224 monocyte differentiation IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030318 melanocyte differentiation IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0035984 cellular response to trichostatin A IEA
 biological_processGO:0042100 B cell proliferation IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045652 regulation of megakaryocyte differentiation IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046928 regulation of neurotransmitter secretion IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0048643 positive regulation of skeletal muscle tissue development IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048667 cell morphogenesis involved in neuron differentiation IEA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0051145 smooth muscle cell differentiation IEA
 biological_processGO:0051963 regulation of synapse assembly IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0055012 ventricular cardiac muscle cell differentiation IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060025 regulation of synaptic activity IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060297 regulation of sarcomere organization IEA
 biological_processGO:0060536 cartilage morphogenesis IEA
 biological_processGO:0060998 regulation of dendritic spine development IEA
 biological_processGO:0061333 renal tubule morphogenesis IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071374 cellular response to parathyroid hormone stimulus IEA
 biological_processGO:0071498 cellular response to fluid shear stress IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IEA
 biological_processGO:0072102 glomerulus morphogenesis IEA
 biological_processGO:0072160 nephron tubule epithelial cell differentiation IEA
 biological_processGO:0090073 positive regulation of protein homodimerization activity IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904753 negative regulation of vascular associated smooth muscle cell migration IEA
 biological_processGO:1905563 negative regulation of vascular endothelial cell proliferation IEA
 biological_processGO:2000111 positive regulation of macrophage apoptotic process IEA
 biological_processGO:2000310 regulation of NMDA receptor activity IEA
 biological_processGO:2000311 regulation of AMPA receptor activity IEA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IEA
 biological_processGO:2000987 positive regulation of behavioral fear response IEA
 biological_processGO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis IEA
 biological_processGO:2001016 positive regulation of skeletal muscle cell differentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003680 AT DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001093 TCF3 / transcription factor 3 / P15806* / P15923* / Transcription factor E2-alpha *  / complex / reaction
 ENSGALG00000019384 MAPK12 / mitogen-activated protein kinase 12 / O08911* / P53778*  / complex / reaction
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / complex / reaction
 ENSGALG00000040023 MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex / reaction
 ENSGALG00000010936 MYF6 / myogenic factor 6 / P15375* / P23409*  / complex / reaction
 ENSGALG00000000172 MYOG / P17920 / Myogenin / P12979* / P15173*  / reaction / complex






 

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