ENSMUSG00000027247


Mus musculus

Features
Gene ID: ENSMUSG00000027247
  
Biological name :Arhgap1
  
Synonyms : Arhgap1 / Q5FWK3 / Rho GTPase-activating protein 1
  
Possible biological names infered from orthology : Q07960
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E1
Gene start: 91649860
Gene end: 91672326
  
Corresponding Affymetrix probe sets: 10473965 (MoGene1.0st)   1424307_at (Mouse Genome 430 2.0 Array)   1451309_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000088105
Ensembl peptide - ENSMUSP00000106961
Ensembl peptide - ENSMUSP00000106962
Ensembl peptide - ENSMUSP00000106963
NCBI entrez gene - 228359     See in Manteia.
MGI - MGI:2445003
RefSeq - XM_011239457
RefSeq - NM_001145902
RefSeq - NM_146124
RefSeq - XM_006499248
RefSeq - XM_006499249
RefSeq - XM_006499250
RefSeq - XM_006499251
RefSeq - XM_006499244
RefSeq - XM_006499245
RefSeq - XM_006499246
RefSeq - XM_006499247
RefSeq Peptide - NP_001139374
RefSeq Peptide - NP_666236
swissprot - Q5FWK3
swissprot - A2AH25
Ensembl - ENSMUSG00000027247
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap1ENSDARG00000024324Danio rerio
 ARHGAP1ENSGALG00000042357Gallus gallus
 Q07960ENSG00000175220Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9CXP4 / Arhgap8 / Rho GTPase-activating protein 8 / P85298* / PRR5-ARHGAP8* / PRR5-ARHGAP8 readthrough*ENSMUSG0000007895443
2 / Prune2 / Q52KR3 / Q8WUY3* / prune homolog 2*ENSMUSG0000003912618
Bnip2 / O54940 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 / Q12982* / BCL2 interacting protein 2*ENSMUSG0000001195817
Atcay / Q8BHE3 / Caytaxin / Q86WG3* / ATCAY, caytaxin*ENSMUSG0000003495816
Bnipl / Q99JU7 / Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein / Q7Z465* / BCL2 interacting protein like*ENSMUSG0000002811514


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR008936  Rho GTPase activation protein
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction ISO
 biological_processGO:0016197 endosomal transport IEA
 biological_processGO:0033572 transferrin transport ISO
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0098706 ferric iron import across plasma membrane ISO
 biological_processGO:2001136 negative regulation of endocytic recycling ISO
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0010008 endosome membrane ISO
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0097443 sorting endosome ISO
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0017137 Rab GTPase binding ISO
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zpbptm1Zuk/Zpbp+,Zpbp2tm1Zuk/Zpbp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zpbptm1Zuk/Zpbp+,Zpbp2tm1Zuk/Zpbp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zpbptm1Zuk/Zpbp+,Zpbp2tm1Zuk/Zpbp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zpbptm1Zuk/Zpbp+,Zpbp2tm1Zuk/Zpbp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
Show

Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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